Childhood T-lineage acute lymphoblastic leukemia: Management and outcome at a tertiary care center in North India
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To assess the clinical features, prognostic factors and outcome of childhood T-ALL in comparison with B-lineage ALL, treated with a uniform treatment regimen (MCP 841).
Pediatric oncology division of a tertiary care institution in Northern India.
Retrospective analysis of clinical data and survival outcome.
60 children with T-ALL and 139 with Blineage ALL, and less than 15 years of age treated over 15 years.
T-ALL was observed in 30%. High risk features at presentation (age ≥10 years, WBC >50,000/mm3, mediastinal mass, and CNS leukemia) were significantly more frequent in T-ALL as compared to B-lineage ALL (P=0.049, P<0.001, P<0.001 and P=0.02, respectively). Fifty five of 60 T-ALL patients (91.7%) achieved complete remission after induction therapy. There were 3 induction and 10 remission deaths while 11 (18.3%) relapsed. The overall survival and event-free survival of T-lineage ALL (61.5±7.6 and 49.9±7.4, respectively) were similar to that of B-lineage patients (68.7±4.7 and 47.1±5.1, respectively). National Cancer Institute risk groups emerged as significant prognostic factor for event free survival only in B-lineage patients.
Even though high risk features were significantly more frequent in T-ALL, survival outcome was similar to that of B-lineage patients. None of the routinely described prognostic parameters significantly impacted survival.
- Childhood T-lineage acute lymphoblastic leukemia: Management and outcome at a tertiary care center in North India
Volume 48, Issue 10 , pp 785-790
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- Acute lymphoblastic leukemia
- Author Affiliations
- 1. Department of Pediatrics, Division of Pediatric Oncology, All India Institute of Medical Sciences, New Delhi, India
- 2. Pediatric Oncology & Hematology, Apollo Center for Advanced Pediatrics, Indraprastha Apollo Hospital, Sarita Vihar, New Delhi, 110 076, India