Neurotherapeutics

, Volume 11, Issue 3, pp 508–526

Deep Brain Stimulation for the Treatment of Epilepsy: Circuits, Targets, and Trials

  • Nealen G. Laxpati
  • Willard S. Kasoff
  • Robert E. Gross
Review

DOI: 10.1007/s13311-014-0279-9

Cite this article as:
Laxpati, N.G., Kasoff, W.S. & Gross, R.E. Neurotherapeutics (2014) 11: 508. doi:10.1007/s13311-014-0279-9

Abstract

Deep brain stimulation (DBS) has proven remarkably safe and effective in the treatment of movement disorders. As a result, it is being increasingly applied to a range of neurologic and psychiatric disorders, including medically refractory epilepsy. This review will examine the use of DBS in epilepsy, including known targets, mechanisms of neuromodulation and seizure control, published clinical evidence, and novel technologies. Cortical and deep neuromodulation for epilepsy has a long experimental history, but only recently have better understanding of epileptogenic networks, precise stereotactic techniques, and rigorous trial design combined to improve the quality of available evidence and make DBS a viable treatment option. Nonetheless, underlying mechanisms, anatomical targets, and stimulation parameters remain areas of active investigation.

Key Words

Epilepsydeep brain stimulationneuromodulationcentromedian nucleusanterior nucleusSANTE

Supplementary material

13311_2014_279_MOESM1_ESM.pdf (501 kb)
ESM 1(PDF 500 kb)

Copyright information

© The American Society for Experimental NeuroTherapeutics, Inc. 2014

Authors and Affiliations

  • Nealen G. Laxpati
    • 1
    • 3
  • Willard S. Kasoff
    • 4
  • Robert E. Gross
    • 1
    • 2
    • 3
  1. 1.Department of NeurosurgeryEmory University School of MedicineAtlantaUSA
  2. 2.Department of NeurologyEmory University School of MedicineAtlantaUSA
  3. 3.Coulter Department of Biomedical EngineeringGeorgia Institute of TechnologyAtlantaUSA
  4. 4.Division of Neurosurgery, Department of SurgeryUniversity of ArizonaTucsonUSA