Neurotherapeutics

, Volume 10, Issue 1, pp 34–43

Humoral-Targeted Immunotherapies in Multiple Sclerosis

Review

DOI: 10.1007/s13311-012-0164-3

Cite this article as:
Lulu, S. & Waubant, E. Neurotherapeutics (2013) 10: 34. doi:10.1007/s13311-012-0164-3

Summary

The continuous improvements of our understanding of the pathophysiological changes that occur in multiple sclerosis (MS) have translated into many novel therapeutic agents at different stages of development. These agents target more specifically the innate or the adaptive immune response. We will review agents available or under development that target the humoral pathways of the adaptive immune response. As such, humoral targeted immunotherapies that are being developed for MS are discussed herein: rituximab, ocrelizumab, and ofatumumab show promise as B-cell depleting agents. Other agents, such as atacicept were suspended during development in MS due to increased inflammatory activity versus the placebo. Although most agents were tested in relapsing-remitting forms of MS, rituximab and ocrelizumab have both been studied in progressive MS, whereas ocrelizumab only is currently moving forward in primary progressive MS trials. We provide an overview of agents available and under development that target the humoral response and include their mechanisms of action, safety profiles, and results of clinical trials.

Keywords

Novel therapeuticsB-cellMonoclonal antibodiesHumoral therapiesRelapsing-remittingProgressive

Supplementary material

13311_2012_164_MOESM1_ESM.pdf (511 kb)
ESM 1(PDF 510 kb)

Copyright information

© The American Society for Experimental NeuroTherapeutics, Inc. 2012

Authors and Affiliations

  1. 1.UCSF Multiple Sclerosis CenterSan FranciscoUSA