Neurotherapeutics

, Volume 10, Issue 1, pp 111–123

Neuroinflammatory Imaging Biomarkers: Relevance to Multiple Sclerosis and its Therapy

Review

DOI: 10.1007/s13311-012-0155-4

Cite this article as:
Tourdias, T. & Dousset, V. Neurotherapeutics (2013) 10: 111. doi:10.1007/s13311-012-0155-4

Abstract

Magnetic resonance imaging is an established tool in the management of multiple sclerosis (MS). Loss of blood brain barrier integrity assessed by gadolinium (Gd) enhancement is the current standard marker of MS activity. To explore the complex cascade of the inflammatory events, other magnetic resonance imaging, but also positron emission tomographic markers reviewed in this article are being developed to address active neuroinflammation with increased sensitivity and specificity. Alternative magnetic resonance contrast agents, positron emission tomographic tracers and imaging techniques could be more sensitive than Gd to early blood brain barrier alteration, and they could assess the inflammatory cell recruitment and/or the associated edema accumulation. These markers of active neuroinflammation, although some of them are limited to experimental studies, could find great relevance to complete Gd information and thereby increase our understanding of acute lesion pathophysiology and its noninvasive follow-up, especially to monitor treatment efficacy. Furthermore, such accurate markers of inflammation combined with those of neurodegeneration hold promise to provide a more complete picture of MS, which will be of great benefit for future therapeutic strategies.

Keywords

Multiple sclerosisInflammationImaging biomarkersBlood brain barrierContrast agentEdema

Supplementary material

13311_2012_155_MOESM1_ESM.pdf (510 kb)
ESM 1(PDF 510 kb)

Copyright information

© The American Society for Experimental NeuroTherapeutics, Inc. 2012

Authors and Affiliations

  1. 1.INSERM Unit 1049 Neuroinflammation, Imagerie et Thérapie de la Sclérose en PlaquesUniversité de BordeauxBordeauxFrance
  2. 2.CHU de Bordeaux, Service de Neuroimagerie Diagnostique et ThérapeutiqueBordeauxFrance