Updates in Surgery

, Volume 65, Issue 1, pp 53–57

Tryptase-positive mast cells and angiogenesis in keloids: a new possible post-surgical target for prevention

Authors

    • Chair of Clinical SurgeryUniversity of Catanzaro “Magna Graecia” Medical School
  • Valeria Zuccalà
    • Department of PathologyUniversity of Catanzaro Medical School
  • Rosa Patruno
    • Surgery UnitNational Cancer Institute Giovanni Paolo II
  • Emilio Russo
    • Chair of Pharmacology, Department of Health ScienceUniversity of Catanzaro Medical School
  • Maria Luposella
    • Chair of Cardiovascular DiseaseUniversity of Catanzaro Medical School
  • Andrea Amorosi
    • Department of PathologyUniversity of Catanzaro Medical School
  • Giuseppina Vescio
    • Chair of Clinical SurgeryUniversity of Catanzaro “Magna Graecia” Medical School
  • Giuseppe Sammarco
    • Chair of Clinical SurgeryUniversity of Catanzaro “Magna Graecia” Medical School
  • Severino Montemurro
    • Surgery UnitNational Cancer Institute Giovanni Paolo II
  • Giovambattista De Sarro
    • Chair of Pharmacology, Department of Health ScienceUniversity of Catanzaro Medical School
  • Rosario Sacco
    • Chair of Clinical SurgeryUniversity of Catanzaro “Magna Graecia” Medical School
  • Girolamo Ranieri
    • Interventional Radiology Unit with Integrated Section of Medical Oncology, National Cancer Institute, Giovanni Paolo II
Original Article

DOI: 10.1007/s13304-012-0183-y

Cite this article as:
Ammendola, M., Zuccalà, V., Patruno, R. et al. Updates Surg (2013) 65: 53. doi:10.1007/s13304-012-0183-y

Abstract

Literature data indicate that mast cells (MCs) are involved in angiogenesis through the release of several pro-angiogenetic factors among which tryptase, a serine protease stored in MC granules, is one of the most active. However, no data are available concerning the role of MCs during keloids’ angiogenesis. In this study, we evaluated the correlations of the number of MCs positive to tryptase (MCDPT) and microvascular density (MVD) within a series of 15 keloids and 10 normotrophic scars, by means of immunohistochemistry and image analysis methods. Data demonstrated a significant difference of MVD and MCDPT between keloids and normotrophic scars and a significant correlation between MVD and MCDPT in keloids. Our results suggest that tryptase-positive MCs might play a key role in keloids’ angiogenesis. In this context, several tryptase inhibitors might be clinically evaluated as a possible new anti-angiogenetic approach to prevent keloid formation after surgery.

Keywords

AngiogenesisTryptaseMast cellsKeloidsTreatment

Copyright information

© Springer-Verlag Italia 2012