Tumor Biology

, Volume 37, Issue 11, pp 14513–14536

Natural products against cancer angiogenesis

  • El Bairi Khalid
  • EL-Meghawry EL-Kenawy Ayman
  • Heshu Rahman
  • Guaadaoui Abdelkarim
  • Agnieszka Najda
Review

DOI: 10.1007/s13277-016-5364-8

Cite this article as:
Khalid, E.B., Ayman, EM.EK., Rahman, H. et al. Tumor Biol. (2016) 37: 14513. doi:10.1007/s13277-016-5364-8

Abstract

The process of angiogenesis is quite well-known nowadays. Some medicines and extracts affecting this process are already used routinely in supporting the conventional treatment of many diseases that are considered angiogenic such as cancer. However, we must be aware that the area of currently used drugs of this type is much narrower than the theoretical possibilities existing in therapeutic angiogenesis. Plant substances are a large and diverse group of compounds that are found naturally in fruits, vegetables, spices, and medicinal plants. They also have different anticancer properties. The aim of this literature review article is to present the current state of knowledge concerning the molecular targets of tumor angiogenesis and the active substances (polyphenols, alkaloids, phytohormones, carbohydrates, and terpenes) derived from natural sources, whose activity against cancer angiogenesis has been confirmed.

Keywords

Natural productsAngiogenesisTargetsChemopreventionCancer

Abbreviations

AFGF

Acidic fibroblast growth factor

AP-1

Activator protein 1

AIF

Apoptosis-inducing factor

Akt

Ak strain thymoma

α-DFMO

α-Difluoromethylornithine

Ang

Angiogenin

ANGPT

Angiopoietin

APAF

Apoptotic protease-activating factor

ATF-4

Activating transcription factor 4

BAP

6-Benzylaminopurine

Bax

Bcl-2-associated X protein

Bcl-2

B cell lymphoma 2

bFGF

Basic fibroblast growth factor

CAM

Chorioallantoic membrane

CD151

Cluster of differentiation 151

Cdc42

Cell division control protein 42 homolog

CDK

Cyclin-dependent kinase

clAP

Calf-intestinal alkaline phosphatase

COX-2

Cyclooxygenase-2

CYP4F3

Leukotriene-B(4) omega-hydroxylase 2

Diablo

Direct IAP-binding protein with low pI

DLL4

Delta-like ligand 4

DMXAA

Dimethyl xanthenyl acetic acid

DNA

Deoxyribonucleic acid

E2(PGE2)

Prostaglandin E2

ECs

Endothelial cells

EGF

Epidermal growth factor

EGFL7

EGF-like domain-containing protein 7

ERK

Extracellular signal-regulated kinases

FasL

Fas ligand

FGF

Fibroblast growth factor

GM-CSF

Granulocyte-macrophage colony-stimulating factor

GSH

Glutathione

ROS

Reactive oxygen species

HER2

Human epidermal receptor 2

HGF

Hepatocyte growth factor

HIF

Hypoxia-inducible factor

IL-8

Interleukin-8

JAK

Janus kinase

JNK

c-Jun N-terminal kinases

LOX

Lipoxygenase

MAP

Mitogen-activated protein

MCP-1

Monocyte chemoattractant protein 1

MRI

Magnetic resonance imaging

mTOR

Mammalian target of rapamycin

NF-κB

Nuclear factor kappa-light-chain-enhancer of activated B cells

NRPs

Neuropilins

pAK

p21 activated kinase

PARP

Poly ADP ribose polymerase

PDGF

Platelet-derived growth factor

PEDF

Pigment epithelium-derived factor

PERK

PKR-like endoplasmic reticulum kinase

PI3K

Phosphatidylinositol-3-kinase

PIGF

Phosphatidylinositol-glycan biosynthesis class F protein

PLGF

Placental growth factor

PTN

Pleiotrophin

Sema3

Semaphorin-3

SLC7A11

Sodium-independent glutamate transporter

GCLC

Glutamate-cysteine ligase catalytic subunit

NRF-2

Nuclear factor (erythroid-derived 2)-like 2

Smac

Second mitochondria-derived activator of caspases

STING

Stimulator of interferon genes

TGF-β

Transforming growth factor-β

TNF-α

Tumor necrosis factor-α

TSP-1

Thrombospondin-1

uPA

Urokinase-type plasminogen activator

VEGF

Vascular endothelial growth factor

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2016

Authors and Affiliations

  • El Bairi Khalid
    • 1
  • EL-Meghawry EL-Kenawy Ayman
    • 2
    • 3
  • Heshu Rahman
    • 4
    • 5
  • Guaadaoui Abdelkarim
    • 6
  • Agnieszka Najda
    • 7
  1. 1.Independent Research Team in Cancer Biology and Bioactive Compounds, Faculty of Medicine and PharmacyUniversity Mohammed 1stOujdaMorocco
  2. 2.Department of Molecular Biology GEBRIUniversity of Sadat CitySadatEgypt
  3. 3.Pathology Department, College of MedicineTaif UniversityTaifSaudi Arabia
  4. 4.Department of Veterinary Clinical Diagnosis, Faculty of Veterinary MedicineUniversity Putra MalaysiaUPM SerdangMalaysia
  5. 5.Department of Medical Laboratory ScienceKomar University of Science and TechnologySulaimani CityIraq
  6. 6.Laboratory of Genetics and Biotechnology (LGB), Faculty of SciencesMohammed 1st University (UMP)OujdaMorocco
  7. 7.Quality Laboratory of Vegetable and Medicinal Materials, Department of Vegetable Crops and Medicinal PlantsUniversity of Life Sciences in LublinLublinPoland