Tumor Biology

, Volume 35, Issue 10, pp 9859–9877

Association between the CYP3A4 and CYP3A5 polymorphisms and cancer risk: a meta-analysis and meta-regression

  • Xiao-Feng He
  • Zhi-Zhong Liu
  • Jian-Jun Xie
  • Wei Wang
  • Ya-Ping Du
  • Yu Chen
  • Wu Wei
Research Article

DOI: 10.1007/s13277-014-2241-1

Cite this article as:
He, X., Liu, Z., Xie, J. et al. Tumor Biol. (2014) 35: 9859. doi:10.1007/s13277-014-2241-1

Abstract

Previously published data on the association between CYP3A4 A392G and CYP3A5 Met235Thr polymorphisms and the risk of cancer remained controversial. Thus, we performed a meta-analysis to investigate the association between cancer susceptibility and CYP3A4 A392G (18,629 cases and 22,323 controls from 49 studies) and CYP3A5 Met235Thr polymorphisms (14,334 cases and 18,183 from 39 studies) in different inheritance models. We used odds ratios with 95 % confidence intervals to assess the strength of the association. Overall, significant association was found between CYP3A4 A392G polymorphism and cancer susceptibility (dominant model, odds ratio (OR) = 1.19; 95 % confidence interval (CI) = 1.03–1.38). In the further stratified and sensitivity analyses, significant increased prostate cancer risk was found among Caucasians (dominant model, OR = 1.88; 95 % CI = 1.20–2.95; recessive model, OR = 2.10; 95 % CI = 1.23–3.60; additive model, OR = 1.80, 95 % CI = 1.24–2.63; homozygous model, OR = 2.34, 95 % CI = 1.36–4.03; heterozygote model, OR = 1.79, 95 % CI = 1.11–2.89) for CYP3A4 A392G. For CYP3A5 Met235Thr polymorphism, no significant association was found among overall analysis and any subgroup analysis. In summary, this meta-analysis suggests that CYP3A4 A392G polymorphism is associated with increased prostate cancer risk among Caucasians and CYP3A5 Met235Thr polymorphism is not associated with the risk of cancer.

Keywords

CYP3A4CYP3A5PolymorphismCancerMeta-analysis

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Xiao-Feng He
    • 1
  • Zhi-Zhong Liu
    • 2
  • Jian-Jun Xie
    • 2
  • Wei Wang
    • 2
  • Ya-Ping Du
    • 2
  • Yu Chen
    • 2
  • Wu Wei
    • 3
  1. 1.Department of ResearchPeace Hospital of Changzhi Medical CollegeChangzhiPeople’s Republic of China
  2. 2.Department of GastroenterologyThe Second People’s Hospital of ZhuhaiZhuhaiPeople’s Republic of China
  3. 3.Department of HematologyPeace Hospital of Changzhi Medical CollegeChangzhiPeople’s Republic of China