Tumor Biology

, Volume 35, Issue 4, pp 3509–3515

The variant interleukin 1f7 rs3811047 G>A was associated with a decreased risk of gastric cardiac adenocarcinoma in a Chinese Han population

  • Xu Wang
  • Jun Yin
  • Liang Zheng
  • Liming Wang
  • Yijun Shi
  • Weifeng Tang
  • Guowen Ding
  • Chao Liu
  • Ruiping Liu
  • Suocheng Chen
  • Haiyong Gu
Research Article

DOI: 10.1007/s13277-013-1463-y

Cite this article as:
Wang, X., Yin, J., Zheng, L. et al. Tumor Biol. (2014) 35: 3509. doi:10.1007/s13277-013-1463-y
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Abstract

To investigate the association between gastric cardiac adenocarcinoma (GCA) and six functional single nucleotide polymorphisms (SNPs) including interleukin 1A (IL1A) rs1800587 C>T, IL1B rs16944 G>A, IL1f7 rs3811047 G>A, IL3 rs40401 C>T, IL3 rs2073506 G>A, and IL7Rα rs6897932 A>G. We performed a hospital-based case–control study to evaluate the genetic effects of these SNPs. A total of 243 GCA cases and 476 controls were enrolled in this study. A custom-by-design 48-Plex SNPscanTM kit was used to determine the genotypes. The IL1f7 rs3811047 G>A polymorphism was significantly associated with a decreased risk of GCA either in the single locus analyses or the recessive genetic model. However, there was no significant association between the other five SNPs and GCA risk. These results elucidated that the functional polymorphism, IL1f7 rs3811047 G>A, might contribute to GCA susceptibility. However, the statistical power of our study was limited, large well-designed studies and further functional investigations are needed to confirm our findings.

Keywords

IL1f7PolymorphismsGastric cardiac adenocarcinomaMolecular epidemiology

Abbreviations

CI

Confidential interval

GCA

Gastric cardiac adenocarcinoma

IL7Rα

Interleukin 7 receptor alpha

OR

Odds ratio

SNPs

Single nucleotide polymorphisms

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Xu Wang
    • 1
  • Jun Yin
    • 1
  • Liang Zheng
    • 2
  • Liming Wang
    • 3
  • Yijun Shi
    • 1
  • Weifeng Tang
    • 1
  • Guowen Ding
    • 1
  • Chao Liu
    • 1
  • Ruiping Liu
    • 4
  • Suocheng Chen
    • 1
  • Haiyong Gu
    • 1
    • 5
  1. 1.Department of Cardiothoracic SurgeryAffiliated People’s Hospital of Jiangsu UniversityZhenjiangChina
  2. 2.Department of Cardiothoracic SurgeryThe First People’s Hospital of Changzhou and The Third Affiliated Hospital of Suzhou UniversityChangzhouChina
  3. 3.Cancer institute, Department of chemotherapyPeople’s Hospital Affiliated to Jiangsu UniversityZhenjiangChina
  4. 4.Department of OrthopedicsAffiliated Hospital of Nanjing Medical University, Changzhou Second People’s HospitalChangzhouChina
  5. 5.Department of Cardiothoracic SurgeryAffiliated People’s Hospital of Jiangsu UniversityZhenjiangChina