Tumor Biology

, Volume 35, Issue 3, pp 2367–2372

Genetic polymorphism of DNA methyltransferase 3B 149 C>T and risk of colorectal cancer: a meta-analysis

Research Article

DOI: 10.1007/s13277-013-1312-z

Cite this article as:
Meng, Q., Zhang, J., Lian, B. et al. Tumor Biol. (2014) 35: 2367. doi:10.1007/s13277-013-1312-z
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Abstract

Numerous studies have investigated the risk of colorectal cancer (CRC) associated with the polymorphism of DNA methyltransferase 3B (DNMT3B) 149 C>T, but results have been inconsistent. We performed this meta-analysis to drive a more precise estimation of the association between this polymorphism and risk of CRC. A comprehensive search was conducted to identify all case–control studies of the −149C>T polymorphism of DNMT3B and CRC risk. A total of seven eligible studies, including 2,666 cases and 4,022 controls, relating the DNMT3B polymorphism of −149C>T to the risk of CRC were identified. It suggested no significant associations between −149C>T polymorphism of DNMT3B gene and the risk of developing CRC in the recessive, dominant, and co-dominant models (for CC versus TT: OR = 0.90, 95 % CI = 0.90–1.25, Pheterogeneity = 0.37; for recessive model: OR = 0.54, 95 % CI = 0.28–1.04, Pheterogeneity = 0.00001; for dominant model: OR = 1.07, 95% CI = 0.93–1.23, Pheterogeneity = 0.83; and for C allele versus T allele: OR = 0.70, 95 % CI = 0.43–1.13, Pheterogeneity = 0.00001). In the subgroup analysis, there is no significant associations were also found in European populations (for CC versus TT: OR = 1.09, 95 % CI = 0.92–1.30, Pheterogeneity = 0.88; for recessive model: OR = 1.00, 95 % CI = 0.88–1.13, Pheterogeneity = 0.14; for dominant model: OR = 1.50, 95 % CI = 0.89–2.54, Pheterogeneity = 0.00001; and for C allele versus T allele: OR = 0.70, 95 % CI = 0.38–1.28, Pheterogeneity = 0.00001). In conclusion, no significant association was found between the −149C>T polymorphisms in DNMT3B and CRC susceptibility.

Keywords

DNA methyltransferase 3BColorectal cancerPolymorphismMeta-analysis

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Qingkai Meng
    • 1
  • Jingru Zhang
    • 1
  • Bo Lian
    • 1
  • Chun Song
    • 1
  1. 1.Department of Intestine SurgeryLiaoning Tumour HospitalLiaoningChina