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The protein p17 signaling pathways in cancer

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Tumor Biology

Abstract

P17 is a novel neuronal protein expressed under physiological conditions only at very low levels in other tissues. Accumulating data indicate its crucial involvement in tumorigenic effects. Using molecular, cellular, and biocomputational methods, the current study unraveled p17 mode of action. Data indicate that mitochondria-associated p17 interacts with the proteins TMEM115, YPEL3, ERP44, CDK5RAP, and NNAT. Moreover, p17 drives the cell cycle into the G0/G1 phase and enhances survival of proliferating cells. Interference with p17 activities thus might become a novel option to influence also the tumor suppressor protein p53 signaling pathways for the treatment of tumors.

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Acknowledgments

This study was supported by Hanyang University.

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  1. Graduate School of Biomedical Science and Engineering, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, 133-791, Republic of Korea

    Klaus Heese

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Correspondence to Klaus Heese.

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Heese, K. The protein p17 signaling pathways in cancer. Tumor Biol. 34, 4081–4087 (2013). https://doi.org/10.1007/s13277-013-0999-1

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