Tumor Biology

, Volume 34, Issue 6, pp 3555–3559

IDH1 mutation is associated with improved overall survival in patients with glioblastoma: a meta-analysis

  • Hong-Bin Cheng
  • Wu Yue
  • Chen Xie
  • Ru-You Zhang
  • Shao-Shan Hu
  • Zhi Wang
Research Article

DOI: 10.1007/s13277-013-0934-5

Cite this article as:
Cheng, HB., Yue, W., Xie, C. et al. Tumor Biol. (2013) 34: 3555. doi:10.1007/s13277-013-0934-5

Abstract

Previous studies proposed that isocitrate dehydrogenase 1 (IDH1) mutation was associated with improved survival in patients with glioblastoma, but those studies reported varying estimates and yielded inconclusive results. The purpose of the present study was to determine the effect of IDH1 mutation on the prognosis of patients with glioblastoma by performing a meta-analysis. Pubmed and Embase databases were searched for eligible studies. Studies reporting overall survival by IDH1 mutation in patients with glioblastoma were considered potentially eligible for the meta-analysis. For the quantitative aggregation of the survival results, the IDH mutation effect was measured by the pooled hazard ratio (HR) with its 95 % confidence interval (95%CI). Nine studies with a total of 1,669 patients with glioblastoma were finally included into this meta-analysis. Overall, the IDH1 mutation was associated with improved survival in patients with glioblastoma (random effects model HR = 0.45, 95%CI 0.29–0.69, P < 0.001). Sensitivity analysis further showed that the pooled estimates were stable in this meta-analysis. Therefore, the findings from this meta-analysis suggest that IDH1 mutation is associated with improved overall survival in patients with glioblastoma.

Keywords

Glioblastoma IDH1 Prognosis Meta-analysis 

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Hong-Bin Cheng
    • 1
  • Wu Yue
    • 1
  • Chen Xie
    • 1
  • Ru-You Zhang
    • 2
  • Shao-Shan Hu
    • 2
  • Zhi Wang
    • 1
  1. 1.Department of NeurosurgeryThe Fourth Affiliated Hospital of Harbin Medical UniversityHarbinChina
  2. 2.Department of NeurosurgeryThe Second Affiliated Hospital of Harbin Medical UniversityHarbinChina

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