Tumor Biology

, Volume 34, Issue 6, pp 3423–3430

Prognostic value of cyclin E expression in breast cancer: a meta-analysis

Authors

  • Sheng Gao
    • State Key Laboratory of Reproductive Medicine, Department of Breast SurgeryNanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University
  • Jing-Jing Ma
    • State Key Laboratory of Reproductive Medicine, Department of Breast SurgeryNanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University
    • State Key Laboratory of Reproductive Medicine, Department of Breast SurgeryNanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University
Research Article

DOI: 10.1007/s13277-013-0915-8

Cite this article as:
Gao, S., Ma, J. & Lu, C. Tumor Biol. (2013) 34: 3423. doi:10.1007/s13277-013-0915-8

Abstract

Cyclin E is an important regulator of cell cycle progression. Various studies examined the relationship between cyclin E overexpression with the clinical outcome in patients with breast cancer but yielded conflicting results. Electronic databases updated to May 2013 were searched to find relevant studies. A meta-analysis was conducted with eligible studies which quantitatively evaluated the relationship between cyclin E overexpression and survival of patients with breast cancer. Survival data were aggregated and quantitatively analyzed. We conducted a final analysis of 7,759 patients from 23 eligible studies and evaluated the correlation between cyclin E overexpression and survival in patients with breast cancer. Combined hazard ratios suggested that cyclin E overexpression had an unfavorable impact on overall survival (OS) (hazard ratio (HR) = 1.30, 95 % confidence interval (CI), 1.12–1.49) and breast cancer-specific survival (BCSS) (HR = 1.48, 95 % CI, 1.03–1.93), but not disease-free survival (HR = 1.11; 95 % CI, 0.96–1.27) in patients with breast cancer. Significantly, risks were found among stage I–II breast cancer for (HR = 1.75; 95 % CI, 1.30–2.19). Cyclin E overexpression is associated with poor OS and BCSS in breast cancer.

Keywords

Cyclin EBreast cancerPrognosisDisease-free survivalMeta-analysis

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013