Tumor Biology

, Volume 34, Issue 5, pp 2507–2509

Circulating tumor cells in high-risk nonmetastatic colorectal cancer

  • Paola Gazzaniga
  • Walter Gianni
  • Cristina Raimondi
  • Angela Gradilone
  • Giuseppe Lo Russo
  • Flavia Longo
  • Orietta Gandini
  • Silverio Tomao
  • Luigi Frati
Research Commentary

DOI: 10.1007/s13277-013-0752-9

Cite this article as:
Gazzaniga, P., Gianni, W., Raimondi, C. et al. Tumor Biol. (2013) 34: 2507. doi:10.1007/s13277-013-0752-9

Abstract

The identification of patients at higher risk of recurrence after primary colorectal cancer resection is currently one of the challenges facing medical oncologists. Circulating tumor cell (CTC) may represent a surrogate marker of an early spread of disease in patients without overt metastases. Thirty-seven high-risk stages II–III colorectal cancer patients were evaluated for the presence of CTC. Enumeration of CTCs in 7.5 ml of blood was carried out with the FDA-cleared CellSearch system. CTC count was performed after primary tumor resection and before the start of adjuvant therapy. CTC was detected in 22 % of patients with a significant correlation with regional lymph nodes involvement and stage of disease. No significant correlation was found among the presence of CTC and other clinicopathological parameters. These data suggest that CTCs detection might help in the selection of high-risk stage II colorectal cancer patient candidates for adjuvant chemotherapy.

Keywords

Circulating tumor cellsEarly colorectal cancerPrognosis

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Paola Gazzaniga
    • 1
  • Walter Gianni
    • 2
  • Cristina Raimondi
    • 1
  • Angela Gradilone
    • 1
  • Giuseppe Lo Russo
    • 3
  • Flavia Longo
    • 1
  • Orietta Gandini
    • 1
  • Silverio Tomao
    • 3
  • Luigi Frati
    • 4
  1. 1.Department of Molecular MedicineSapienza University of RomeRomeItaly
  2. 2.Scientific Direction, HCP Study CenterIRCCS San Raffaele PisanaRomeItaly
  3. 3.Department of Medico-Surgical Sciences and BiotechnologiesSapienza University of RomeRomeItaly
  4. 4.Department of Experimental MedicineSapienza University of RomeRomeItaly