Tumor Biology

, Volume 34, Issue 2, pp 1215–1224

CYP2E1 polymorphisms and colorectal cancer risk: a HuGE systematic review and meta-analysis

  • Ou Jiang
  • Rongxing Zhou
  • Daoquan Wu
  • Yu Liu
  • Wenjian Wu
  • Nansheng Cheng
Research Article

DOI: 10.1007/s13277-013-0664-8

Cite this article as:
Jiang, O., Zhou, R., Wu, D. et al. Tumor Biol. (2013) 34: 1215. doi:10.1007/s13277-013-0664-8

Abstract

Studies investigating the associations between Cytochrome P4502E1 (CYP2E1) polymorphisms and colorectal cancer (CRC) risk report conflicting results. We conducted a meta-analysis to assess the association between CYP2E1 gene Rsa I/Pst I, Dral T/A and 96-bp insertion polymorphisms and CRC susceptibility. Two investigators independently searched the Medline, Embase, CNKI, Wanfang, and Chinese Biomedicine Databases. Summary odds ratios (ORs) and 95 % confidence intervals (95 % CIs) for CYP2E1 polymorphisms and CRC were calculated in a fixed-effect model (the Mantel–Haenszel method) and a random-effects model (the DerSimonian and Laird method) when appropriate. Ultimately, 12, 5, and 4 studies were found to be eligible for meta-analyses of Rsa I/Pst I, Dral T/A, and 96-bp insertion polymorphisms, respectively. Our analysis suggested that the variant genotype of Rsa I/Pst I were associated with a significantly increased CRC risk (c2/c2 vs. c1/c1, OR = 1.36, 95 % CI = 1.04–1.77; recessive model, OR = 1.35, 95 % CI = 1.04–1.75). Moreover, similar results were observed between CYP2E1 96-bp insertion polymorphism and CRC risk (dominant model, OR = 1.25, 95 % CI = 1.07–1.45), while no association was observed between CYP2E1 Dral T/A polymorphism and CRC susceptibility in any genetic model. No publication bias was found in the present study. This meta-analysis shows that CYP2E1 Rsa I/Pst I and 96-bp insertion polymorphisms may be associated with CRC risk. The CYP2E1 Dral T/A polymorphism was not detected to be related to the risk for CRC.

Keywords

Colorectal cancerCYP2E1Gene polymorphismMeta-analysis

Abbreviations

CRC

Colorectal cancer

CYP2E1

Cytochrome P4502E1

OR

Odds ratio

CI

Confidence interval

PCR

Polymerase chain reaction

RFLP

Restriction fragment length polymorphism

SNP

Single nucleotide polymorphisms

HWE

Hardy–Weinberg equilibrium

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Ou Jiang
    • 1
  • Rongxing Zhou
    • 2
  • Daoquan Wu
    • 1
  • Yu Liu
    • 1
  • Wenjian Wu
    • 1
  • Nansheng Cheng
    • 2
  1. 1.Department of Surgical OncologyThe Second People’s Hospital of NeijiangNeijiangChina
  2. 2.Department of Biliary SurgeryWest China Hospital of Sichuan UniversityChengduChina