Tumor Biology

, Volume 34, Issue 2, pp 1171–1176

BMI, apolipoprotein B/apolipoprotein A-I ratio, and insulin resistance in patients with prolactinomas: a pilot study in a Chinese cohort

  • Xiao-Bing Jiang
  • Dong-Sheng He
  • Zhi-Gang Mao
  • Xiang Fan
  • Ni Lei
  • Bin Hu
  • Bing-Bing Song
  • Yong-Hong Zhu
  • Hai-Jun Wang
Research Article

DOI: 10.1007/s13277-013-0660-z

Cite this article as:
Jiang, XB., He, DS., Mao, ZG. et al. Tumor Biol. (2013) 34: 1171. doi:10.1007/s13277-013-0660-z

Abstract

Deranged metabolic profiles and insulin resistance (IR) have been documented in patients with prolactinomas. Few data are yet available on the apolipoprotein (apo) B/apoA-I ratio and its relationship with IR in patients with prolactinomas. This study was aimed to evaluate the level of apoB/apoA-I ratio and its association with IR in a Chinese subgroup with prolactinomas. Twenty-three prolactinoma patients and 20 healthy controls were enrolled in this study. The clinical anthropometric parameters and laboratory evaluation were collected. Insulin sensitivity was estimated using homeostatic model assessment [homeostasis model assessment of insulin resistance (HOMA-IR)]. Waist circumference and body weight index (BMI) were significantly higher in patients with prolactinomas than those in the controls (p < 0.05). Meanwhile, the prevalence of general and abdominal obesity seemed more pronounced in male patients compared to that in healthy subjects (57.14 vs. 0 % and 71.43 vs. 16.7 %, respectively). Furthermore, fasting glucose, insulin, HOMA-IR, triglyceride, and apoB/apoA-I ratio were also significantly higher in prolactinoma patients, but with lower level of apoA-I (p < 0.05). Univariate regression analysis revealed that prolactin, waist circumference, BMI, and presence of hypogonadism were significantly associated with IR (p < 0.05). However, only BMI [odds ratio (OR) = 1.937, 95 % confidence interval (CI) 1.112–3.375, p = 0.02] and prolactin (OR = 5.173, 95 % CI 1.073–24.94, p = 0.041) were shown to be independent predictors for the presence of IR in multivariate logistic analysis. This study confirmed the altered metabolic profile, including body weight gain, IR, disordered lipids, and apolipoproteins in prolactinoma patients. Prolactin and BMI were independently associated with IR. The effect of apoB/apoA-I ratio on IR is warranted to be determined in further studies.

Keywords

Pituitary adenoma Prolactin Insulin resistance Apolipoprotein 

Abbreviations

ApoB/apoA-I ratio

Apolipoprotein B/apolipoprotein A-I ratio

BMI

Body mass index

fT4

Free T4

GH

Growth hormone

HDL-C

High-density lipoprotein cholesterol, HOMA-IR, Homeostasis model assessment of insulin resistance

IL-6

Interleukin 6

IR

Insulin resistance

LDL-C

Low-density lipoprotein cholesterol

Lp(a)

Lipoprotein(a)

PRL

Prolactin

PRLR

Prolactin receptor

TC

Total cholesterol

TG

Triglyceride

WC

Waist circumference

WHR

Ratio of waist to hip

TSH

Thyrotropin-stimulating hormone

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Xiao-Bing Jiang
    • 1
  • Dong-Sheng He
    • 1
  • Zhi-Gang Mao
    • 1
  • Xiang Fan
    • 1
  • Ni Lei
    • 2
  • Bin Hu
    • 1
  • Bing-Bing Song
    • 2
  • Yong-Hong Zhu
    • 2
  • Hai-Jun Wang
    • 1
  1. 1.Key Laboratory of Pituitary Adenoma in Guangdong Province and Department of NeurosurgeryFirst Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina
  2. 2.Key Laboratory of Pituitary Adenoma in Guangdong Province and Department of Histology and Embryology, Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouChina