Tumor Biology

, Volume 34, Issue 1, pp 379–385

EphB4 is overexpressed in gliomas and promotes the growth of glioma cells

Research Article

DOI: 10.1007/s13277-012-0560-7

Cite this article as:
Chen, T., Liu, X., Yi, S. et al. Tumor Biol. (2013) 34: 379. doi:10.1007/s13277-012-0560-7

Abstract

Glioma is one of the most common solid tumors, and the molecular mechanism for this disease is poorly understood. EphB4 tyrosine kinase receptor has been involved in various physiologic and pathologic processes, and the role of EphB4 in tumorigenesis has recently attracted much interest. However, its function in glioma remains largely unknown. In this study, we explored the function of EphB4 in glioma. We found that the expression of EphB4 was significantly upregulated in clinical glioma samples. Overexpression of EphB4 in glioma cell lines accelerated cell growth and tumorigenesis. In contrast, downregulation of EphB4 inhibited cell growth. Furthermore, we showed that EphB4 promoted cell growth by promoting EGFR signaling. Taken together, our findings suggest that EphB4 plays an important role in the progression of glioma by stimulating cell growth and EphB4 might be a potential therapeutic target for glioma.

Keywords

EphB4 Glioma EGFR Tumorigenesis 

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2012

Authors and Affiliations

  1. 1.State Key Laboratory of Respiratory Disease for Allergy at Shengzhen University, School of MedicineShenzhen UniversityShenzhenPeople’s Republic of China
  2. 2.Teaching and Research Section of EpidemiologyHunan Normal UniversityChangshaPeople’s Republic of China
  3. 3.Operation Room, Shanghai Children’s Medical Center, School of medicineShanghai Jiaotong UniversityShanghaiPeople’s Republic of China
  4. 4.Department of Neurosurgery, Renji Hospital, School of MedicineShanghai Jiaotong UniversityShanghaiPeople’s Republic of China