Research Article

Tumor Biology

, Volume 34, Issue 1, pp 301-307

First online:

Human papillomavirus infection and papillary squamous cell carcinoma in the head and neck region

  • Chao-Hui YangAffiliated withDepartment of Otolaryngology, Kaohsiung Chang Gung Memorial HospitalGraduate Institute of Clinical Medical Sciences, Chang Gung University College of MedicineChang Gung University College of Medicine
  • , Chao-Cheng HuangAffiliated withGraduate Institute of Clinical Medical Sciences, Chang Gung University College of MedicineDepartment of Pathology, Kaohsiung Chang Gung Memorial HospitalChang Gung University College of Medicine Email author 
  • , Ming-Tse KoAffiliated withGraduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine
  • , Yu-Ching WeiAffiliated withDepartment of Pathology, Kaohsiung Chang Gung Memorial HospitalChang Gung University College of Medicine
  • , Chung-Feng HwangAffiliated withDepartment of Otolaryngology, Kaohsiung Chang Gung Memorial HospitalChang Gung University College of Medicine Email author 

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

Papillary squamous cell carcinoma (PSCC) is a rare variant of SCC in the head and neck region. The role of human papillomavirus (HPV) infection in PSCC is still unclear. We retrospectively reviewed 11 PSCCs in our institute over a 21-year period and compared the HPV status of PSCCs with 26 squamous cell papillomas (SCPs). Polymerase chain reaction (PCR) amplification to detect HPV DNA and in situ hybridization (ISH) were performed to analyze the relationship between the papillary lesions and HPV infection. Immunohistochemical (IHC) staining for p16 protein expression was used to analyze the PSCC specimens. Nine of 11 (82 %), eight of 11 (73 %), and eight of 11 (73 %) PSCC samples were found to be HPV positive by PCR, ISH, and IHC staining for p16 protein expression, respectively. PSCC had a significantly higher rate of HPV infection than SCP by PCR (p = 0.002) and ISH (p = 0.001) analysis. This study presents different HPV status in two papillary neoplasms and may help to clarify the unique morphological and biological characteristics of head and neck PSCC.

Keywords

Papillary squamous cell carcinoma Squamous cell papilloma Human papillomavirus p16 HNSCC