Tumor Biology

, Volume 33, Issue 6, pp 2041–2051

Quantitative assessment of the association between MTHFR C677T polymorphism and colorectal cancer risk in East Asians

  • Shan Zhong
  • Jia-He Yang
  • Kai Liu
  • B. H. Jiao
  • Zhi-Jie Chang
Research Article

DOI: 10.1007/s13277-012-0463-7

Cite this article as:
Zhong, S., Yang, JH., Liu, K. et al. Tumor Biol. (2012) 33: 2041. doi:10.1007/s13277-012-0463-7

Abstract

A great number of studies regarding the association between MTHFR C677T polymorphism and risk of colorectal cancer (CRC) in East Asians were published, but the results were inconsistent. Thus, a meta-analysis was performed to investigate the association. PubMed, Embase, and CBM databases were searched for eligible publications. Pooled odds ratios (ORs) with 95 % confidence intervals (95 % CIs) were calculated using random or fixed effect models. Finally, 24 case–control studies with a total of 7,230 CRC cases and 9,285 controls were included. Meta-analyses of a total of 24 studies showed there was a statistically significant association between MTHFR C677T polymorphism and decreased CRC risk in East Asians under four genetic models (T versus C, OR = 0.92, 95 % CI 0.85–0.99; TT versus CC, OR = 0.80, 95 % CI 0.69–0.94; TT versus CT/CC, OR = 0.82, 95 % CI 0.71–0.95; TT/CT versus CC, OR = 0.92, 95 % CI 0.86–0.98). The cumulative meta-analyses for the allele contrast (T versus C), homozygote (TT versus CC), dominant (TT/CT versus CC), and recessive (TT versus CT/CC) models all showed a trend of more obvious association as information accumulated by year. Subgroup analyses by country further identified this association in Korea and Japan. This meta-analysis suggests that MTHFR C677T polymorphism is associated with decreased risk of colorectal cancer in East Asians, and MTHFR 677T variant has a protective effect on colorectal cancer.

Keywords

MTHFR C677T Genetic polymorphism Meta-analysis Colorectal cancer 

Supplementary material

13277_2012_463_MOESM1_ESM.doc (32 kb)
ESM 1(DOC 31 kb)

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2012

Authors and Affiliations

  • Shan Zhong
    • 1
    • 2
  • Jia-He Yang
    • 3
  • Kai Liu
    • 3
  • B. H. Jiao
    • 2
  • Zhi-Jie Chang
    • 1
  1. 1.Institute of Biomedicine and School of MedicineTsinghua UniversityBeijingChina
  2. 2.Department of Biochemistry and Molecular BiologySecond Military Medical UniversityShanghaiPeople’s Republic of China
  3. 3.Eastern Hepatobiliary Surgery HospitalSecond Military Medical UniversityShanghaiPeople’s Republic of China

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