Tumor Biology

, Volume 33, Issue 5, pp 1467–1476

Cyclin D1 G870A polymorphism and lung cancer risk: a meta-analysis

Authors

  • Jianming Liu
    • Department of Respiratory diseasesthe Third Xiangya Hospital of Central South University
    • National Hepatobiliary and Enteric Surgery Research Center of Ministry of Health
    • National Hepatobiliary and Enteric Surgery Research Center of Ministry of Health
  • Yangde Zhang
    • National Hepatobiliary and Enteric Surgery Research Center of Ministry of Health
  • Shenghua Sun
    • Department of Respiratory diseasesthe Third Xiangya Hospital of Central South University
  • Caigao Zhong
    • Department of Health ToxicologySchool of Public Health of Central South University
  • Xinmin Liu
    • Department of Health ToxicologySchool of Public Health of Central South University
Research Article

DOI: 10.1007/s13277-012-0397-0

Cite this article as:
Liu, J., Liao, Q., Zhang, Y. et al. Tumor Biol. (2012) 33: 1467. doi:10.1007/s13277-012-0397-0

Abstract

Many studies have investigated the association between Cyclin D1 (CCND1) G870A polymorphism and lung cancer risk, but the impact of CCND G870A polymorphism on lung cancer is unclear owing to the obvious inconsistence among those studies. This study aimed to quantify the strength of association between CCND1 G870A polymorphism and lung cancer risk. We searched the PubMed, Embase, and Wangfang databases for articles on studies relating the CCND1 G870A polymorphism to the risk of lung cancer in humans. We estimated summary odds ratios (ORs) with their confidence intervals (CIs) to assess the association. Meta-analyses of total studies showed that CCND1 G870A polymorphism was associated with lung cancer risk under three genetic models (ORA versus G = 1.13, 95 % CI 1.03–1.24; ORAA versus GG = 1.20, 95 % CI 1.07–1.35; ORAA versus AG + GG = 1.23, 95 % CI 1.02–1.50). Meta-analyses of studies with high quality showed that CCND1 G870A polymorphism was associated with lung cancer risk under two genetic models (ORA versus G = 1.08, 95 % CI 1.02–1.15; ORAA versus GG = 1.17, 95 % CI 1.04–1.32). Subgroup analyses by ethnicity and sensitivity analyses further identified the significant association above. No evidence of publication bias was observed. Meta-analyses of available data show a significant association between the CCND1 G870A polymorphism and lung cancer risk, and CCND1 G870A polymorphic variant A contributes to increased risk of lung cancer.

Keywords

Cyclin D1Lung cancerGene polymorphismMeta-analysis

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2012