Tumor Biology

, Volume 33, Issue 3, pp 809–816

CYP1B1 Leu432Val polymorphism and colorectal cancer risk among Caucasians: a meta-analysis

  • Yong Xie
  • Guo-Qing Liu
  • Xiong-Ying Miao
  • Yi Liu
  • Wei Zhou
  • De-Wu Zhong
Research Article

DOI: 10.1007/s13277-011-0298-7

Cite this article as:
Xie, Y., Liu, GQ., Miao, XY. et al. Tumor Biol. (2012) 33: 809. doi:10.1007/s13277-011-0298-7

Abstract

Studies investigating the association between cytochrome P450 1B1 (CYP1B1) Leu432Val (432 C/G, rs1056836) polymorphism and colorectal cancer (CRC) risk report conflicting results. The aim of this study was to quantitatively summarize the evidence for such a relationship. Two investigators independently searched the Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Databases. Summary odds ratios (ORs) and 95% confidence intervals (95% CIs) for CYP1B1 polymorphism and CRC were calculated in a fixed-effects model and a random-effects model when appropriate. The pooled ORs were performed for co-dominant model (GG vs. CC, GC vs. CC), dominant model (GG + GC vs. CC), and recessive model (GG vs. GC + CC). This meta-analysis included ten case–control studies, which included 8,466 CRC cases and 9,301 controls. Overall, the variant genotypes (GG and GC) of the 432 C/G were not associated with CRC risk when compared with the wild-type CC homozygote (GG vs. CC, OR = 1.01, 95% CI = 0.93–1.10; GC vs. CC, OR = 0.97, 95% CI = 0.90–1.04), without any between-study heterogeneity. Similarly, no associations were found in the dominant and recessive models (dominant model, OR = 0.98, 95% CI = 0.92–1.05; recessive model, OR = 1.03, 95% CI = 0.96–1.11). Limiting the analysis to the studies within Hardy–Weinberg equilibrium, the results were persistent and robust. When stratifying for country, matched control and source of controls, no evidence of significant association was observed in any subgroup. No publication bias was found in the present study. No association is found between the CYP1B1 Leu432Val polymorphism and risk of CRC among Caucasians.

Keywords

Colorectal cancer Polymorphism CYP1B1 Meta-analysis 

Abbreviations

CRC

colorectal cancer

OR

odds ratio

CI

confidence interval

CYP1B1

cytochrome P450 1B1

SNP

single nucleotide polymorphisms

HWE

Hardy–Weinberg equilibrium

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2011

Authors and Affiliations

  • Yong Xie
    • 1
  • Guo-Qing Liu
    • 1
  • Xiong-Ying Miao
    • 1
  • Yi Liu
    • 1
  • Wei Zhou
    • 1
  • De-Wu Zhong
    • 1
  1. 1.Department of Hepatobiliary Surgery, The Second Xiangya HospitalCentral South UniversityChangshaChina