Molecular & Cellular Toxicology

, Volume 10, Issue 2, pp 197–206

The anti-inflammatory effects of Alisma herb extract on allergic asthma mouse model

  • Min-Hee Shin
  • Yu Jin Park
  • Ki-Suk Kim
  • Dong Hyuk Cho
  • In Joon Uh
  • Kang-Hoon Kim
  • In Jin Ha
  • Won-Seok Chung
  • Hee-Jae Jung
  • Sung-Ki Jung
  • Hyeung-Jin Jang
Original Paper

DOI: 10.1007/s13273-014-0021-z

Cite this article as:
Shin, MH., Park, Y.J., Kim, KS. et al. Mol. Cell. Toxicol. (2014) 10: 197. doi:10.1007/s13273-014-0021-z

Abstract

Asthma is a complex chronic inflammatory disorder in the airway accompanying airway hyperresponsiveness, airway obstruction and airway wall remodeling. Alisma canaliculatum (AC) is a constituent of Cheong-Sang-Bo-Ha-Tang (CSBHT) which had been frequently prescribed to treat the respiratory disease in traditional Korean medicine. Here, we investigated the precise mechanism of the anti-inflammatory activity of AC extract using ovalbumin-induced mouse asthma model. AC extract administration improved the mouse AHR, and alleviated the thickened airway epithelium. These effects may mediate by the inhibitory effect of AC extract on nuclear factor kappa B (NF-κB) activation. And the inhibitory effect regulated the inducible nitric oxide synthase (iNOS) expression at the transcription level. We determined the AC extract metabolites through UPLC/ESI-QTOF-MS and identified 10-O-methyl-alismoxide, 11-deoxyalisol C, 4-12-dihydroxyguaian-6,10-diene, alismol, alismoxide, alisol B, alisol B 23-acetate, alisol C 23-acetate, and alisolide. This study provides the full understanding about the anti-asthmatic effect of AC extract for the first time.

Keywords

Alisma canaliculatum (AC) Asthma Antiinflammatory Inducible nitric oxide synthase (iNOS) NF-κB 

Copyright information

© The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Min-Hee Shin
    • 1
  • Yu Jin Park
    • 1
  • Ki-Suk Kim
    • 1
  • Dong Hyuk Cho
    • 1
  • In Joon Uh
    • 1
  • Kang-Hoon Kim
    • 1
  • In Jin Ha
    • 2
  • Won-Seok Chung
    • 1
  • Hee-Jae Jung
    • 1
  • Sung-Ki Jung
    • 1
  • Hyeung-Jin Jang
    • 1
  1. 1.College of Korean Medicine, Institute of Korean MedicineKyung Hee UniversitySeoulKorea
  2. 2.Integrated Metabolomics Research Group, Seoul CenterKorea Basic Science InstituteSeoulKorea