, Volume 4, Issue 4, pp 291-308
Date: 20 Feb 2013

Computer Simulations in Stroke Prevention: Design Tools and Virtual Strategies Towards Procedure Planning

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Abstract

Stroke is a heterogeneous disease caused by a sustained interruption of the blood supply to part of the brain. Prevention and treatment of this disease is of primary importance as it has been estimated to be the second leading cause of death worldwide. Due to the large number of possible origins there is no general strategy for preventive treatment and evidence based recommendations are given. However major causes of stroke can be confined to few vascular districts. More and more evidence is supporting the hypothesis that biomechanical and hemodynamic parameters can be related to catastrophic cerebrovascular events. In this context structural and fluidodynamic computer simulations offer an optimal tool to quantify these predictors. On the other hand the advances in medical imaging allow providing realistic in vivo conditions (such as reliable anatomical geometries and initial mechanical state) for patient specific analysis. This paper reviews the progress and the state of art of numerical simulation used to analyze the early stages and the progression of the disease as well as their potential as tool for risk assessment, for treatment outcome and procedure planning.

Associate Editor Ajit P Yoganathan oversaw the review of this article.