Protein & Cell

, Volume 3, Issue 10, pp 755–761

Transformation: how do nematode sperm become activated and crawl?

Authors

  • Xuan Ma
    • Laboratory of Noncoding RNA, Institute of BiophysicsChinese Academy of Sciences
  • Yanmei Zhao
    • Laboratory of Noncoding RNA, Institute of BiophysicsChinese Academy of Sciences
  • Wei Sun
    • Laboratory of Noncoding RNA, Institute of BiophysicsChinese Academy of Sciences
    • Graduate University of Chinese Academy of Sciences
    • Department of Chemical and Biological EngineeringUbe National College of Technology
    • Laboratory of Noncoding RNA, Institute of BiophysicsChinese Academy of Sciences
Mini-Review

DOI: 10.1007/s13238-012-2936-2

Cite this article as:
Ma, X., Zhao, Y., Sun, W. et al. Protein Cell (2012) 3: 755. doi:10.1007/s13238-012-2936-2

Abstract

Nematode sperm undergo a drastic physiological change during spermiogenesis (sperm activation). Unlike mammalian flagellated sperm, nematode sperm are amoeboid cells and their motility is driven by the dynamics of a cytoskeleton composed of major sperm protein (MSP) rather than actin found in other crawling cells. This review focuses on sperm from Caenorhabditis elegans and Ascaris suum to address the roles of external and internal factors that trigger sperm activation and power sperm motility. Nematode sperm can be activated in vitro by several factors, including Pronase and ionophores, and in vivo through the TRY-5 and SPE-8 pathways. Moreover, protease and protease inhibitors are crucial regulators of sperm maturation. MSP-based sperm motility involves a coupled process of protrusion and retraction, both of which have been reconstituted in vitro. Sperm motility is mediated by phosphorylation signals, as illustrated by identification of several key components (MPOP, MFPs and MPAK) in Ascaris and the characterization of GSP-3/4 in C. elegans.

Keywords

spermiogenesismajor sperm proteinsperm motility
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© Higher Education Press and Springer-Verlag Berlin Heidelberg 2012