Protein & Cell

, Volume 3, Issue 7, pp 497–507

Functional regulation of monocyte-derived dendritic cells by microRNAs

Review

DOI: 10.1007/s13238-012-0042-0

Cite this article as:
Zhan, Y. & Wu, L. Protein Cell (2012) 3: 497. doi:10.1007/s13238-012-0042-0

Abstract

Dendritic cells (DCs) as a rare type of leukocytes play an important role in bridging the innate and adaptive immune system. A subset of DCs, monocyte-derived dendritic cells (moDCs), exists in very low numbers at steady state but become abundant in inflammatory states. These inflammation-associated DCs are potent producers of pro-inflammatory cytokines and potent inducers of T helper differentiation. They behave as a “double-edge” sword so that they not only mediate protective immunity but also immuno-pathology. It is still incompletely understood how their function is regulated. Emerging evidence indicates that microRNAs (miRNAs), as a new class of gene regulators, potently regulate the function of moDCs. Here we summarize recent progress in this area.

Keywords

dendritic cells microRNA function 

Copyright information

© Higher Education Press and Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.The Walter and Eliza Hall Institute of Medical ResearchParkvilleAustralia
  2. 2.Department of Medical BiologyUniversity of MelbourneParkvilleAustralia
  3. 3.Tsignhua University and Peking University Joint Center for Life Sciences and Tsinghua University School of MedicineBeijingChina

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