Transcriptional activators and activation mechanisms
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- Ma, J. Protein Cell (2011) 2: 879. doi:10.1007/s13238-011-1101-7
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Transcriptional activators are required to turn on the expression of genes in a eukaryotic cell. Activators bound to the enhancer can facilitate either the recruitment of RNA polymerase II to the promoter or its elongation. This article examines a few selected issues in understanding activator functions and activation mechanisms.