Protein & Cell

, Volume 2, Issue 11, pp 879–888

Transcriptional activators and activation mechanisms


DOI: 10.1007/s13238-011-1101-7

Cite this article as:
Ma, J. Protein Cell (2011) 2: 879. doi:10.1007/s13238-011-1101-7


Transcriptional activators are required to turn on the expression of genes in a eukaryotic cell. Activators bound to the enhancer can facilitate either the recruitment of RNA polymerase II to the promoter or its elongation. This article examines a few selected issues in understanding activator functions and activation mechanisms.


activator transcription co-activator enhancer promoter signal transduction development 

Copyright information

© Higher Education Press and Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.Division of Biomedical Informatics, Division of Developmental Biology, Cincinnati Children’s Research FoundationUniversity of Cincinnati College of MedicineCincinnatiUSA

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