Protein & Cell

, Volume 2, Issue 6, pp 456–462

The impact of acetylation and deacetylation on the p53 pathway

Mini-Review

DOI: 10.1007/s13238-011-1063-9

Cite this article as:
Brooks, C.L. & Gu, W. Protein Cell (2011) 2: 456. doi:10.1007/s13238-011-1063-9

Abstract

The p53 tumor suppressor is a sequence-specific transcription factor that undergoes an abundance of post-translational modifications for its regulation and activation. Acetylation of p53 is an important reversible enzymatic process that occurs in response to DNA damage and genotoxic stress and is indispensible for p53 transcriptional activity. p53 was the first non-histone protein shown to be acetylated by histone acetyl transferases, and a number of more recent in vivo models have underscored the importance of this type of modification for p53 activity. Here, we review the current knowledge and recent findings of p53 acetylation and deacetylation and discuss the implications of these processes for the p53 pathway.

Keywords

p53Mdm2acetylationdeacetylationdestabilizationubiquitinationtranscriptional activation and stability

Copyright information

© Higher Education Press and Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.Stemline Therapeutics, Inc.New YorkUSA
  2. 2.Institute for Cancer Genetics, and Department of Pathology College of Physicians & SurgeonsColumbia UniversityNew YorkUSA