Protein & Cell

, Volume 2, Issue 3, pp 237–249

The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A

Authors

  • Sunil K. Verma
    • Department of Medical Oncology, Medical Sciences DivisionThe University of Oxford
    • Ovarian Cancer Group, CRUK Molecular Oncology Laboratories, Weatherall Institute of Molecular MedicineJohn Radcliffe Hospital
    • Protein Phosphorylation Laboratory, London Research InstituteCRUK Lincoln’s Inn Fields Laboratories
  • Trivadi S. Ganesan
    • Department of Medical Oncology, Medical Sciences DivisionThe University of Oxford
    • Ovarian Cancer Group, CRUK Molecular Oncology Laboratories, Weatherall Institute of Molecular MedicineJohn Radcliffe Hospital
  • Uday Kishore
    • Center for Infection, Immunity and Disease Mechanisms, Biosciences, School of Health Sciences and Social CareBrunel University
    • Protein Phosphorylation Laboratory, London Research InstituteCRUK Lincoln’s Inn Fields Laboratories
    • Kings College London, The Division of Cancer StudiesSection of Cancer Cell Biology and Imaging
Research Article

DOI: 10.1007/s13238-011-1028-z

Cite this article as:
Verma, S.K., Ganesan, T.S., Kishore, U. et al. Protein Cell (2011) 2: 237. doi:10.1007/s13238-011-1028-z

Abstract

Rap1A is a small G protein implicated in a spectrum of biological processes such as cell proliferation, adhesion, differentiation, and embryogenesis. The downstream effectors through which Rap1A mediates its diverse effects are largely unknown. Here we show that Rap1A, but not the related small G proteins Rap2 or Ras, binds the tumor suppressor Ras association domain family 1A (RASSF1A) in a manner that is regulated by phosphorylation of RASSF1A. Interaction with Rap1A is shown to influence the effect of RASSF1A on microtubule behavior.

Keywords

RASSF1ARap1Amicrotubulevimentinprotein-protein interaction

Supplementary material

13238_2011_1028_MOESM1_ESM.pdf (145 kb)
Supplementary material, approximately 144 KB.

Copyright information

© Higher Education Press and Springer-Verlag Berlin Heidelberg 2011