Protein & Cell

, Volume 1, Issue 9, pp 820–829

Nucleosome assembly and epigenetic inheritance


  • Mo Xu
    • Graduate ProgramPeking Union Medical College and Chinese Academy of Medical Sciences
    • National Institute of Biological Sciences
    • National Institute of Biological Sciences

DOI: 10.1007/s13238-010-0104-0

Cite this article as:
Xu, M. & Zhu, B. Protein Cell (2010) 1: 820. doi:10.1007/s13238-010-0104-0


In eukaryotic cells, histones are packaged into octameric core particles with DNA wrapping around to form nucleosomes, which are the basic units of chromatin (Kornberg and Thomas, 1974). Multicellular organisms utilise chromatin marks to translate one single genome into hundreds of epigenomes for their corresponding cell types. Inheritance of epigenetic status is critical for the maintenance of gene expression profile during mitotic cell divisions (Allis et al., 2006). During S phase, canonical histones are deposited onto DNA in a replication-coupled manner (Allis et al., 2006). To understand how dividing cells overcome the dilution of epigenetic marks after chromatin duplication, DNA replication coupled (RC) nucleosome assembly has been of great interest. In this review, we focus on the potential influence of RC nucleosome assembly processes on the maintenance of epigenetic status.


nucleosome assemblyepigenetic inheritanceDNA replication coupled

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© Higher Education Press and Springer-Verlag Berlin Heidelberg 2010