Protein & Cell

, Volume 1, Issue 7, pp 616–620

A loop matters for FTO substrate selection


DOI: 10.1007/s13238-010-0082-2

Cite this article as:
Han, Z., Huang, N., Niu, T. et al. Protein Cell (2010) 1: 616. doi:10.1007/s13238-010-0082-2


Recent studies have unequivocally established the link between FTO and obesity. FTO was biochemically shown to belong to the AlkB-like family DNA/RNA demethylase. However, FTO differs from other AlkB members in that it has unique substrate specificity and contains an extended C-terminus with unknown functions. Insight into the substrate selection mechanism and a functional clue to the C-terminus of FTO were gained from recent structural and biochemical studies. These data would be valuable to design FTO-specific inhibitors that can be potentially translated into therapeutic agents for treatment of obesity or obesity-related diseases.

Copyright information

© Higher Education Press and Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Zhifu Han
    • 1
  • Ning Huang
    • 1
  • Tianhui Niu
    • 1
  • Jijie Chai
    • 1
    • 2
  1. 1.National Institute of Biological SciencesBeijingChina
  2. 2.College of Biological Sciences and BiotechnologyTsinghua UniversityBeijingChina

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