Protein & Cell

, Volume 1, Issue 3, pp 218–226

MAPK signaling in inflammation-associated cancer development


DOI: 10.1007/s13238-010-0019-9

Cite this article as:
Huang, P., Han, J. & Hui, L. Protein Cell (2010) 1: 218. doi:10.1007/s13238-010-0019-9


Mitogen-activated protein (MAP) kinases comprise a family of protein-serine/threonine kinases, which are highly conserved in protein structures from unicellular eukaryotic organisms to multicellular organisms, including mammals. These kinases, including ERKs, JNKs and p38s, are regulated by a phosphorelay cascade, with a prototype of three protein kinases that sequentially phosphorylate one another. MAPKs transduce extracellular signals into a variety of cellular processes, such as cell proliferation, survival, death, and differentiation. Consistent with their essential cellular functions, MAPKs have been shown to play critical roles in embryonic development, adult tissue homeostasis and various pathologies. In this review, we discuss recent findings that reveal the profound impact of these pathways on chronic inflammation and, particularly, inflammation-associated cancer development.

Copyright information

© Higher Education Press and Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  1. 1.Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological SciencesChinese Academy of SciencesShanghaiChina
  2. 2.Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life SciencesXiamen UniversityXiamenChina

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