Oral Hypoglycemic Agents in pregnancy: An Update
- Nagandla KavithaAffiliated withDepartment of Obstetrics and Gynecology, Melaka Manipal Medical College Email author
- , Somsubhra DeAffiliated withDepartment of Obstetrics and Gynecology, Melaka Manipal Medical College
- , Sachchithanantham KanagasabaiAffiliated withDepartment of Obstetrics and Gynecology, Melaka Manipal Medical College
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Traditionally, insulin has been the gold standard in the management of Type 2 diabetes in pregnancy and gestational diabetes. However, insulin therapy can be inconvenient because of the needs for multiple injections, its associated cost, pain at the injection site, need for refrigeration, and skillful handling of the syringes. This has led to the exploration of oral hypoglycemic agents as an alternative to insulin therapy.
This review examines and evaluates the evidences on the efficacy, safety, and current recommendations of oral hypoglycemic agents.
The evidence of this study supports the use of glyburide and metformin in the management of Type 2 diabetes and gestational diabetes with no increased risk of neonatal hypoglycemia or congenital anomalies. The safety of these oral hypoglycemic agents are limited to the prenatal period and more randomized controlled trials are required to provide information on the long-term follow up on neonatal and cognitive development.
KeywordsOral hypoglycemic agents Gestational diabetes mellitus Type 2 diabetes
- Oral Hypoglycemic Agents in pregnancy: An Update
The Journal of Obstetrics and Gynecology of India
Volume 63, Issue 2 , pp 82-87
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- Oral hypoglycemic agents
- Gestational diabetes mellitus
- Type 2 diabetes