Oral Hypoglycemic Agents in pregnancy: An Update

  • Nagandla Kavitha
  • Somsubhra De
  • Sachchithanantham Kanagasabai
Review Article

DOI: 10.1007/s13224-012-0312-z

Cite this article as:
Kavitha, N., De, S. & Kanagasabai, S. J Obstet Gynecol India (2013) 63: 82. doi:10.1007/s13224-012-0312-z

Abstract

Introduction

Traditionally, insulin has been the gold standard in the management of Type 2 diabetes in pregnancy and gestational diabetes. However, insulin therapy can be inconvenient because of the needs for multiple injections, its associated cost, pain at the injection site, need for refrigeration, and skillful handling of the syringes. This has led to the exploration of oral hypoglycemic agents as an alternative to insulin therapy.

Objectives

This review examines and evaluates the evidences on the efficacy, safety, and current recommendations of oral hypoglycemic agents.

Conclusion

The evidence of this study supports the use of glyburide and metformin in the management of Type 2 diabetes and gestational diabetes with no increased risk of neonatal hypoglycemia or congenital anomalies. The safety of these oral hypoglycemic agents are limited to the prenatal period and more randomized controlled trials are required to provide information on the long-term follow up on neonatal and cognitive development.

Keywords

Oral hypoglycemic agents Gestational diabetes mellitus Type 2 diabetes 

Copyright information

© Federation of Obstetric & Gynecological Societies of India 2013

Authors and Affiliations

  • Nagandla Kavitha
    • 1
  • Somsubhra De
    • 1
  • Sachchithanantham Kanagasabai
    • 1
  1. 1.Department of Obstetrics and GynecologyMelaka Manipal Medical CollegeBukit BaruMalaysia

Personalised recommendations