Emerging sciences and new conceptions of disease; or, beyond the monogenomic differentiated cell lineage
- John Dupré
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This paper will begin with some very broad and general considerations about the kind of biological entities we are. This exercise is motivated by the belief that the view of what we—multicellular eukaryotic organisms—are that is widely assumed by biologists, medical scientists and the general public, is an extremely limited one. It cannot be assumed a priori that a more sophisticated view will make a major difference to the science or practice of medicine, and there are areas of medicine to which it is probably largely irrelevant. However, in this case there are important implications for medicine, or so I shall argue. In particular, it enables us to appreciate fully the potential medical significance of some of the most exciting contemporary advances in general biology, in such fields as epigenetics, metagenomics, and systems biology; and part of this significance is that these advances have raised serious doubts about how we should understand the biological individuals that medicine is generally assumed to aim to treat.
- Allen, T. D., Moore, D. R., Wang, X., Casu, V., May, R., Lerner, M. R., et al. (2008). Dichotomous metabolism of Enterococcus faecalis induced by haematin starvation modulates colonic gene expression. Journal of Medical Microbiology, 57, 1193–1204. CrossRef
- Bollati, V., & Baccarelli, A. (2010). Environmental epigenetics. Heredity, 105, 105–112. CrossRef
- Covic, M., Karaca, E., & Lie, D. C. (2010). Epigenetic regulation of neurogenesis in the adult hippocampus. Heredity, 105, 122–134. CrossRef
- Dawkins, R. (1976). The selfish gene. Oxford: Oxford University Press.
- Dupré, J., & O’Malley, M. A. (2007). Metagenomics and biological ontology. Studies in the History and Philosophy of the Biological and Biomedical Sciences, 38, 834–846. CrossRef
- Dupré, J., & O’Malley, M. A. (2009). Varieties of living things: Life at the intersection of lineage and metabolism. Philosophy and Theory in Biology, 2009. http://hdl.handle.net/2027/spo.6959004.0001.003.
- Harris, R. N., Brucker, R. M., Walke, J. B., Becker, M. H., Schwantes, C. R., Flaherty, D. C., et al. (2009). Skin microbes on frogs prevent morbidity and mortality caused by a lethal skin fungus. The ISME Journal, 3, 818–824. CrossRef
- Hehemann, J., Correc, G., Barbeyron, T., Helbert, W., Czjzek, M., & Michel, G. (2010). Transfer of carbohydrate-active enzymes from marine bacteria to Japanese gut microbiota. Nature, 464, 908–912. CrossRef
- Heijmans, B. T., Tobi, E. W., Stein, A. D., Putter, H., Blauw, G. J., et al. (2008). Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proceedings of the National Academy of Sciences, USA, 105, 17046–17049. CrossRef
- Hill, M. J., Goddard, P., & Williams, R. E. O. (1971). Gut bacteria and aetiology of cancer of the breast. The Lancet, 298, 472–473. CrossRef
- Hirano, S. S., & Upper, C. D. (2000). Bacteria in the leaf ecosystem with emphasis on Pseudomonas syringae: a pathogen, ice nucleus, and epiphyte. Microbiology and Molecular Biology Reviews, 64, 624–653. CrossRef
- Klein, F., Amin Kotb, W. F., & Petersen, I. (2009). Incidence of human papilloma virus in lung cancer. Lung Cancer, 65, 13–18. CrossRef
- Kripke, S. (1980). Naming and necessity. Cambridge: Harvard University Press.
- Lai, Y., Di Nardo, A., Nakatsuji, T., Leichtle, A., Yang, Y., Cogen, A. L., et al. (2009). Commensal bacteria regulate Toll-like receptor 3–dependent inflammation after skin injury. Nature Medicine, 15, 1377–1382. CrossRef
- Méthot, P-O. (forthcoming, 2010). Research traditions and styles of explanation in evolutionary studies of medicine. Journal of Theoretical Medicine and Bioethics.
- Morgan, D. K., & Whitelaw, E. (2008). The case for transgenerational epigenetic inheritance in humans. Mammalian Genome, 19, 394–397. CrossRef
- O’Malley, M. A., & Dupré, J. (2007). Size doesn’t matter: towards a more inclusive philosophy of biology. Biology and Philosophy, 22, 155–191. CrossRef
- Oyama, S., Griffiths, P. E., & Gray, R. D. (Eds.). (2001). Cycles of contingency: Developmental systems and evolution. Cambridge: MIT.
- Paxson, H. (2008). Post-Pasteurian cultures: the microbiopolitics of raw-milk cheese in the United States. Cultural Anthropology, 23, 15–47. CrossRef
- Pradeu, T. (forthcoming). The limits of the self. Immunology and biological identity. Oxford: Oxford University Press.
- Rawls, J. F., Samuel, B. S., & Gordon, J. I. (2004). Gnotobiotic zebrafish reveal evolutionarily conserved responses to the gut microbiota. Proceedings of the National Academy of Sciences, U S A, 101, 4596–4601. CrossRef
- Venkataraman, S., Reddy, S. P., Loo, J., Idamakanti, N., Hallenbeck, P. L., & Reddy, V. S. (2008). Structure of Seneca Valley Virus-001, an oncolytic picornavirus representing a new genus. Structure, 16, 1555–1561. CrossRef
- Webster, N. S., & Blackall, L. L. (2009). What do we really know about sponge-microbial symbioses? The ISME Journal (2009) 3, 1–3, 2003.
- West Eberhard, M. J. (2003). Developmental plasticity and evolution. New York: Oxford University Press.
- Emerging sciences and new conceptions of disease; or, beyond the monogenomic differentiated cell lineage
European Journal for Philosophy of Science
Volume 1, Issue 1 , pp 119-131
- Cover Date
- Print ISSN
- Online ISSN
- Springer Netherlands
- Additional Links
- Gut bacteria
- John Dupré (1)
- Author Affiliations
- 1. Egenis, University of Exeter, Exeter, EX4 4PJ, UK