Does the “new philosophy” in predictive, preventive and personalised medicine require new ethics?
Purchase on Springer.com
$39.95 / €34.95 / £29.95*
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.
This paper maps the ethical issues that arise in the context of personalised medicine. First, it highlights the ethical problems related to increased predictive power of modern diagnostic interventions. Such problems emerge because the ability to identify individuals or groups of individuals that can potentially benefit from a particular therapeutic intervention also raises a question of personal responsibility for health-related behaviour and lifestyle. The second major area of ethical concern is related to health prevention and distributive justice. The paper discusses the ethical challenges brought by the personalised medicine in the context of the Additional Protocol to the Convention on Human Rights and Biomedicine concerning Genetic Testing for Health Purposes. Finally, it notes that the issue of consent in the context of biobanks, the need to rethink the prevalent models of research designs and to communicate relevant findings to the donors of biological materials deserve further discussion.
- Costigliola V. Preface. EPMA J. 2010;1:1–2. CrossRef
- Golubnitschaja O. Time for new guidelines in advanced diabetes care: Paradigm change from delayed interventional approach to predictive, preventive and personalized medicine. EPMA J. 2010;1:3–12. CrossRef
- George B, Cebioglu M, Yeghiazaryan K. Inadequate diabetic care: global figures cry for preventive measures and personalized treatment. EPMA J. 2010;1:13–8. CrossRef
- Gefenas E. Bioethics, professional codes and law In: Pegoraro R, Putoto G, Wray E, editors. Hospital based bioethics: European perspective. Padova: Piccin; 2007:1–17.
- Council of Europe. Additional protocol to the Convention on human rights and biomedicine, concerning genetic testing for health purposes. 2008. http://conventions.coe.int/Treaty/en/Treaties/html/203.htm. Accessed 13 Mar 2011.
- Council of Europe. Explanatory report to the Additional protocol to the Convention on human rights and biomedicine, concerning genetic testing for health purposes, 2008. http://conventions.coe.int/Treaty/EN/Reports/Html/203.htm. Accessed 13 Mar 2011.
- Van Delden J. Tailor made pharmacotherapy: future developments and ethical challenges in the field of pharmacogenomics. Bioethics. 2004;18:303–21. CrossRef
- Safer v.Pack, 677 A.2d 1188 (N.J. App.), appeal denied, 683 A 2 d 1163 (N.J. 1996). Cited in: Clayton EW. Ethical, legal and social implications of genomic medicine. N Engl J Med. 2003;349:562–9.
- UK National Screening Committee. Criteria for appraising the viability, effectiveness and appropriateness of a screening programme. 2011. http://www.screening.nhs.uk/criteria. Accessed 13 Mar 2011.
- Roberts R. Personalized medicine: a reality within this decade. J Cardiovasc Trans Res. 2008;1:11–6. CrossRef
- Khan H. Why health care costs keep rising: what you need to know. Abc News. 2010. http://abcnews.go.com/Politics/HealthCare/health-care-costs-biggest-drivers/story?id=10044091. Accessed 13 Mar 2011.
- Fleck LM. Personalised medicine‘s ragged edge. Hastings Cent Rep. 2010;40:16–8. CrossRef
- Schmidt H. Health responsibility, the Left, and the Right. The Bioethics Forum. 2007. http://www.thehastingscenter.org/Bioethicsforum/Post.aspx?id=440. Accessed 13 Mar 2011.
- Steinbrook R. Imposing personal responsibility for health. Engl J Med. 2006;355:753–6. CrossRef
- UNESCO. International declaration on human genetic data. 2003. http://portal.unesco.org/en/ev.php-URL_ID=17720&URL_DO=DO_TOPIC&URL_SECTION=201.html. Accessed 13 Mar 2011.
- Parliament of Norway. Act No 44 on medical and health research. 2008. http://www.regjeringen.no/upload/HOD/HRA/Helseforskning/Helseforskningsloven%20-%20ENGELSK%20endelig%2029%2006%2009.pdf. Accessed 13 Mar 2011.
- Council of Europe. Recommendation Rec(2006)4 of the Committee of Ministers to Member States on research on biological materials of human origin. 2006. https://wcd.coe.int/wcd/ViewDoc.jsp?id=977859. Accessed 13 Mar 2011.
- Council of Europe. Draft explanatory memorandum to the Draft recommendation Rec(2006)4 of the Committee of Ministers to Member States on research on biological materials of human origin. 2006. https://wcd.coe.int/ViewDoc.jsp?id=961161&Site=COE. Accessed 13 Mar 2011.
- Maschke K. Wanted: human biospecimens. Hastings Cent Rep. 2010;40:21–3. CrossRef
- Hedgecoe AM. Context, ethics and pharmacogenetics. Stud Hist Philos Biol Biomed Sci. 2006;37:566–82.
- Characiejus D, Hodzic J, Jacobs J. “First do no harm” and the importance of prediction in oncology. EPMA J. 2010;1:369–75. CrossRef
- Does the “new philosophy” in predictive, preventive and personalised medicine require new ethics?
The EPMA Journal
Volume 2, Issue 2 , pp 141-147
- Cover Date
- Print ISSN
- Online ISSN
- Springer Netherlands
- Additional Links
- Predictive diagnostics
- Preventive healthcare
- Personalised medicine
- Medical ethics
- Patient benefits and risks
- Author Affiliations
- 1. Faculty of Medicine, Department of Medical History and Ethics, Vilnius University, M.K.Ciurlionio Str. 21/27, Vilnius, LT, 03101, Lithuania
- 2. Faculty of Medicine, Vilnius University, M.K.Ciurlionio Str. 21/27, Vilnius, LT, 03101, Lithuania
- 3. Center for Innovative Medicine, Zygimantu 9, Vilnius, Lithuania