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Apport d’un laboratoire dans la prise en charge des patients atteints de la maladie à virus Ebola et dans la formation des personnels soignants : expérience du Centre de traitement d’Ebola de Forécariah (Guinée) en 2015

Input of a laboratory in the management of patients with Ebola virus disease and in the training of health personnel: experience of the Forecariah Ebola treatment centre (Guinea) in 2015

  • Clinique / Clinics
  • Published:
Bulletin de la Société de pathologie exotique

Résumé

La maladie à virus Ebola (MVE) occasionne une forte létalité, même prise en charge dans un centre de traitement Ebola (CTE). Des examens de laboratoire de base peuvent aider à mieux en comprendre la physiopathologie, à guider le traitement et à établir des conduites à tenir simples sur la base de protocoles adaptés à l’exercice de la médecine en milieu précaire et dangereux pour les soignants. Basé sur quelques cas cliniques de patients pris en charge au CTE de Forécariah en Guinée, tenu par la Croix-Rouge française, cet article décrit les difficiles conditions d’exercice de la médecine auprès des patients atteints de MVE. Il a pour objectif de participer à la réduction des pertes de chance de survie des patients, par l’instauration d’une confrontation clinico-biologique simple et par l’amélioration de la formation des personnels de santé.

Abstract

Ebola virus disease (EVD) is associated with a high lethality rate even when the afflicted are provided with good support in an Ebola treatment center (ETC). Basic laboratory tests can help to better understand the pathophysiology of the disease, to guide treatment and to establish simple protocols and procedures tailored to the practice of medicine in the context of such precarious environment for caregivers. Based on a few clinical cases of patients treated in the ETC of Forecariah, Guinea, run by the French Red Cross, this article describes the difficult conditions associated with the provision of medical practice in this challenging environment, aiming to minimize the casualties in the EVD patient and to train the health staff.

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Références

  1. Baize S, Pannetier D, Oestereich L, et al (2014) Emergence of Zaire Ebola virus disease in Guinea. N Engl J Med 371(15):1418–25

    Article  CAS  PubMed  Google Scholar 

  2. Bwaka MA, Bonnet MJ, Calain P, et al: (1999) Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo: clinical observations in 103 patients. J Infect Dis 179 (Suppl 1):S1–7

    Article  PubMed  Google Scholar 

  3. Elhadj IB, Lamah MC, Fletcher T, et al (2015) Clinical presentation of patients with Ebola virus disease in Conakry Guinea. N Engl J Med 372(1):40–7

    Article  CAS  Google Scholar 

  4. Formenty P, Hatz C, Le Guenno B, et al (1999) Human infection due to Ebola virus, subtype Côte d’Ivoire: clinical and biologic presentation. J Infect Dis 179(Suppl 1):S48–53

    Article  PubMed  Google Scholar 

  5. Georges AJ, Georges-Courbot MC (2000) Fièvres hémorragiques virales. Historique et enseignement des quarante dernières années. Méd Trop 60(2 Suppl):5–19

    CAS  Google Scholar 

  6. Le Guenno B, Formenty P, Wyers M, et al (1995) Isolation and partial characterization of a new strain of Ebola virus. Lancet 345(8960):1271–4

    Article  PubMed  Google Scholar 

  7. Levey AS, Bosch JP, Lewis JB et al (1999) A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 130(6):461–70.

    Article  CAS  PubMed  Google Scholar 

  8. Maganga GD, Kapetshi J, Berthet N, et al (2014) Ebola virus disease in the Democratic Republic of Congo. N Engl J Med 371(22):2083–91

    Article  CAS  PubMed  Google Scholar 

  9. Milleliri J-M (2014) Ebola: une opportunité pour les systèmes de santé. Méd Santé 24(4):341–2

    Google Scholar 

  10. OMS (2015) Rapport de situation sur la flambée de maladie à virus Ebola, 14 janvier 2015

    Google Scholar 

  11. Rapp C (2014). Epidémie à virus Ebola en Afrique de l’Ouest: réalités et perspectives. Méd Santé Trop 24(3):229–31

    PubMed  Google Scholar 

  12. Rollin PE, Bausch DG, Sanchez A (2007) Blood chemistry measurements and D-Dimer levels associated with fatal and nonfatal outcomes in humans infected with Sudan Ebola virus. J Infect Dis 196(Suppl 2):S364–71

    Article  CAS  PubMed  Google Scholar 

  13. Schieffelin JS, Shaffer JG, Goba A, et al (2014) Clinical illness and outcomes in patients with Ebola in Sierra Leone. N Engl J Med 371(22):2092–100

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Thill M., Tolou H (2004) Fièvre hémorragique à virus Ebola. Nouvel opus meurtrier. Méd Trop 64(4):331–3

    CAS  Google Scholar 

  15. Wolf T, Kann G, Becker S, et al (2015) Severe Ebola virus disease with vascular leakage and multiorgan failure: treatment of a patient in intensive care. Lancet 385(9976):1428–35

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Croix-Rouge française, 98 rue Didot, 75014, Paris, France

    B.-A. Gaüzère, J.-C. Nied, B. Beya-Kadiebwe, A. K. Camara, D. Camara, M. L. M. Camara, M. Camara, A. Soumah, M. K. Tounkara, I. B. Camara, B. Simon, T. Tran-Minh & F. L’Hériteau

  2. Service de réanimation polyvalente, CHU de La Réunion, site Centre Hospitalier Félix Guyon, 97400, Saint-Denis, Réunion, France

    B.-A. Gaüzère

  3. Centre René Labusquière, Université de Bordeaux, 33000, Bordeaux, France

    B.-A. Gaüzère

  4. Croix-Rouge canadienne, 170 rue Metcalfe, Ottawa, Ontario, K2P 2P2, Canada

    I. Ouellet & D. Nottebrock

  5. Département de médecine de famille et de médecine d’urgence, Faculté de médecine et des sciences de la santé, Université de Sherbrooke et Service d’urgence, CHU Sherbrooke, Sherbrooke, Canada

    I. Ouellet

  6. UBC Department of Family Medicine, Kelowna General Hospital, Kelowna, 2268 Pandosy street, BC, Canada, VTY 1T2

    D. Nottebrock

  7. Expertise France, 73 rue de Vaugirard, 75006, Paris, France

    V. Monteil, A. Camara, F. Bauffe & A. Camara

  8. Service de maladies infectieuses et tropicales, hôpital de la Pitié-Salpêtrière, 75013, Paris, France

    M. Jaspard

  9. Centre de coordination de la lutte contre les infections nosocomiales (CClin) de l’inter-région Paris-Nord, 8 rue Maria-Helena Vieira da Silva, 75014, Paris, France

    F. L’Hériteau

Authors
  1. B.-A. Gaüzère
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  2. I. Ouellet
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  3. D. Nottebrock
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  4. J.-C. Nied
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  5. B. Beya-Kadiebwe
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  6. A. K. Camara
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  7. D. Camara
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  8. M. L. M. Camara
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  9. M. Camara
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  10. A. Soumah
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  11. M. K. Tounkara
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  12. V. Monteil
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  13. A. Camara
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  14. F. Bauffe
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  15. A. Camara
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  16. I. B. Camara
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  17. B. Simon
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  18. M. Jaspard
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  19. T. Tran-Minh
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  20. F. L’Hériteau
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Corresponding author

Correspondence to B.-A. Gaüzère.

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Gaüzère, BA., Ouellet, I., Nottebrock, D. et al. Apport d’un laboratoire dans la prise en charge des patients atteints de la maladie à virus Ebola et dans la formation des personnels soignants : expérience du Centre de traitement d’Ebola de Forécariah (Guinée) en 2015. Bull. Soc. Pathol. Exot. 109, 248–255 (2016). https://doi.org/10.1007/s13149-016-0491-4

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  • DOI: https://doi.org/10.1007/s13149-016-0491-4

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