Original Papers

Journal of Physiology and Biochemistry

, 67:511

First online:

Effect of zinc supplementation on the distribution of various elements in the serum of diabetic rats subjected to an acute swimming exercise

  • Mursel BicerAffiliated withHigh School of Physical Education and Sport, Selcuk University
  • , Mustafa AkilAffiliated withHasan Dogan High School of Physical Education and Sports, Karabuk University
  • , Abdullah SivrikayaAffiliated withSelcuklu Medical School, Department of Biochemistry, Selcuk University
  • , Ersan KaraAffiliated withHasan Dogan High School of Physical Education and Sports, Karabuk University
  • , Abdulkerim Kasim BaltaciAffiliated withSelcuklu Medical School, Department of Physiology, Selcuk University Email author 
  • , Rasim MogulkocAffiliated withSelcuklu Medical School, Department of Physiology, Selcuk University

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Abstract

The present study aims to examine the effect of supplementation of zinc on the distribution of various elements in the sera of diabetic rats subjected to an acute swimming exercise. A total of 80 Sprague–Dawley-type adult male rats were equally allocated to one of eight groups: Group 1, general; Group 2, zinc-supplemented; Group 3, zinc-supplemented diabetic; Group 4, swimming control; Group 5, zinc-supplemented swimming; Group 6, zinc-supplemented diabetic swimming; Group 7, diabetic swimming; and Group 8, diabetes. The rats were injected with 40 mg/kg/day subcutaneous streptozotocin (STZ) twice, with a 24-h interval between two injections. Zinc was supplemented at a dose of 6 mg/kg/day (ip) for 4 weeks. Blood samples were collected at the end of the 4-week study, and serum levels of lead, cobalt, molybdenum, chrome, sulfur, magnesium, manganese, sodium, potassium, phosphorus, copper, iron, calcium, zinc, and selenium (mg/L) were determined with atomic emission. The lowest molybdenum, chrome, copper, iron, potassium, magnesium, sodium, phosphorus, lead, selenium, and zinc values were obtained in Group 7 and 8. These same parameters were higher in the swimming exercise group (Group 4), relative to all other groups. The values in zinc-supplemented groups were found lower than the values in Group 4, but higher than those in Group 6 and 7. The results obtained from the study demonstrate that acute swimming exercise and diabetes affect the distribution of various elements in the serum, while zinc supplementation can prevent the negative conditions associated with both exercise and diabetes.

Keywords

Diabetes Exercise Zinc supplementation Elements Rat