Journal of Physiology and Biochemistry

, Volume 67, Issue 1, pp 129–139

Biological functions of microRNAs: a review

  • Yong Huang
  • Xing Jia Shen
  • Quan Zou
  • Sheng Peng Wang
  • Shun Ming Tang
  • Guo Zheng Zhang
Mini Review

DOI: 10.1007/s13105-010-0050-6

Cite this article as:
Huang, Y., Shen, X.J., Zou, Q. et al. J Physiol Biochem (2011) 67: 129. doi:10.1007/s13105-010-0050-6

Abstract

MicroRNAs (miRNAs) are a recently discovered family of endogenous, noncoding RNA molecules approximately 22 nt in length. miRNAs modulate gene expression post-transcriptionally by binding to complementary sequences in the coding or 3′ untranslated region of target messenger RNAs (mRNAs). It is now clear that the biogenesis and function of miRNAs are related to the molecular mechanisms of various clinical diseases, and that they can potentially regulate every aspect of cellular activity, including differentiation and development, metabolism, proliferation, apoptotic cell death, viral infection and tumorgenesis. Here, we review recent advances in miRNA research, and discuss the diverse roles of miRNAs in disease.

KeywordsMicroRNABiogenesisFunctionExpressionDisease

Copyright information

© University of Navarra 2010

Authors and Affiliations

  • Yong Huang
    • 1
    • 3
  • Xing Jia Shen
    • 1
    • 3
  • Quan Zou
    • 2
  • Sheng Peng Wang
    • 1
    • 3
  • Shun Ming Tang
    • 1
    • 3
  • Guo Zheng Zhang
    • 1
    • 3
  1. 1.Jiang Su University of Science and TechnologyZhenjiang CityPeople’s Republic of China
  2. 2.School of Information Science and Technology of Xiamen UniversityXiamen CityPeople’s Republic of China
  3. 3.The Key Laboratory of Silkworm and Mulberry Genetic Improvement, Ministry of Agriculture, Sericultural Research InstituteChinese Academy of Agricultural SciencesZhenjiang CityPeople’s Republic of China