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Nrf2 to Pre-condition the Brain Against Injury Caused by Products of Hemolysis After ICH

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Abstract

Brain damage caused by intracerebral hemorrhage is mediated in part by the toxicity of extravascular blood deposited in the brain parenchyma during the hematoma formation. In this paper, we discuss the therapeutic benefits and potential mechanisms associated with the activation of transcription factor Nrf2 regarding its role in defending the brain tissue against toxicity of the blood, a component of secondary injury. We emphasize the pleiotropic capacity of Nrf2 as it recruits multiple pathways aiming at reducing deleterious effects of blood lysis products.

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Acknowledgments

This work was partially supported by the National Institutes of Health, NINDS grants NS060768 and NS064109.

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The authors declare that they have no conflict of interest.

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  1. Stroke Program, Department of Neurology, University of Texas Medical School, 6431 Fannin, Suite 7.210, Houston, TX, 77030, USA

    Xiurong Zhao & Jaroslaw Aronowski

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  1. Xiurong Zhao
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Correspondence to Jaroslaw Aronowski.

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Zhao, X., Aronowski, J. Nrf2 to Pre-condition the Brain Against Injury Caused by Products of Hemolysis After ICH. Transl. Stroke Res. 4, 71–75 (2013). https://doi.org/10.1007/s12975-012-0245-y

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