Translational Stroke Research

, Volume 4, Issue 4, pp 462–475

Gender-Specific Differences in the Central Nervous System’s Response to Anesthesia

  • Lana J. Mawhinney
  • Davita Mabourakh
  • Michael C. Lewis
Original Article

DOI: 10.1007/s12975-012-0229-y

Cite this article as:
Mawhinney, L.J., Mabourakh, D. & Lewis, M.C. Transl. Stroke Res. (2013) 4: 462. doi:10.1007/s12975-012-0229-y


Males and females are physiologically distinct in their responses to various anesthetic agents. The brain and central nervous system (CNS), the main target of anesthesia, are sexually dimorphic from birth and continue to differentiate throughout life. Accordingly, gender has a substantial impact on the influence of various anesthetic agents in the brain and CNS. Given the vast differences in the male and female CNS, it is surprising to find that females are often excluded from basic and clinical research studies of anesthesia. In animal research, males are typically studied to avoid the complication of breeding, pregnancy, and hormonal changes in females. In clinical studies, females are also excluded for the variations that occur in the reproductive cycle. Being that approximately half of the surgical population is female, the exclusion of females in anesthesia-related research studies leaves a huge knowledge gap in the literature. In this review, we examine the reported sex-specific differences in the central nervous system’s response to anesthesia. Furthermore, we suggest that anesthesia researchers perform experiments on both sexes to further evaluate such differences. We believe a key goal of research studying the interaction of the brain and anesthesia should include the search for knowledge of sex-specific mechanisms that will improve anesthetic care and management in both sexes.


AnesthesiaBrainCentral nervous systemGender differencesReview

Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Lana J. Mawhinney
    • 1
  • Davita Mabourakh
    • 2
  • Michael C. Lewis
    • 3
  1. 1.The Miami Project to Cure Paralysis, Department of Neurological SurgeryUniversity of Miami Miller School of MedicineMiamiUSA
  2. 2.College of Arts and ScienceUniversity of MiamiMiamiUSA
  3. 3.Graduate Medical EducationUniversity of Miami Miller School of MedicineMiamiUSA