Hormones and Cancer

, Volume 5, Issue 1, pp 42–50

Prolactin Receptor Expression and Breast Cancer: Relationships with Tumor Characteristics among Pre- and Post-menopausal Women in a Population-Based Case–Control Study from Poland

  • Jessica M. Faupel-Badger
  • Maire A. Duggan
  • Mark E. Sherman
  • Montserrat Garcia-Closas
  • Xiaohong R. Yang
  • Jolanta Lissowska
  • Louise A. Brinton
  • Beata Peplonska
  • Barbara K. Vonderhaar
  • Jonine D. Figueroa
Original Paper

DOI: 10.1007/s12672-013-0165-7

Cite this article as:
Faupel-Badger, J.M., Duggan, M.A., Sherman, M.E. et al. HORM CANC (2014) 5: 42. doi:10.1007/s12672-013-0165-7

Abstract

Previous studies have found an association between elevated circulating prolactin levels and increased risk of breast cancer. Prolactin stimulates breast cancer cell proliferation, migration, and survival via binding to the cell-surface prolactin receptor. The association of prolactin receptor expression with breast tumorigenesis remains unclear as studies that have focused on this association have had limited sample size and/or information about tumor characteristics. Here, we examined the association of prolactin expression with tumor characteristics among 736 cases, from a large population-based case–control study of breast cancer conducted in Poland (2000–2003), with detailed risk factor and pathology data. Tumors were centrally reviewed and prepared as tissue microarrays for immunohistochemical analysis of prolactin receptor expression. Association of prolactin receptor expression across strata of tumor characteristics was evaluated using χ2 analysis and logistic regression. Prolactin receptor expression did not vary by menopausal status; therefore, data from pre- and post-menopausal women were combined in the analyses. Approximately 83 % of breast cancers were categorized as strong prolactin receptor staining. Negative/low prolactin receptor expression was independently associated with poorly differentiated (p = 1.2 × 10−08) and larger tumors (p = 0.0005). These associations were independent of estrogen receptor expression. This is the largest study to date in which the association of prolactin receptor expression with tumor characteristics has been evaluated. These data provide new avenues from which to explore the associations of the prolactin/prolactin receptor signaling network with breast tumorigenesis.

Supplementary material

12672_2013_165_MOESM1_ESM.doc (256 kb)
Supplementary Fig. 1(DOC 256 kb)

Copyright information

© Springer Science+Business Media New York (outside the USA) 2013

Authors and Affiliations

  • Jessica M. Faupel-Badger
    • 1
  • Maire A. Duggan
    • 2
  • Mark E. Sherman
    • 3
  • Montserrat Garcia-Closas
    • 3
    • 5
  • Xiaohong R. Yang
    • 4
  • Jolanta Lissowska
    • 6
  • Louise A. Brinton
    • 3
  • Beata Peplonska
    • 7
  • Barbara K. Vonderhaar
    • 8
  • Jonine D. Figueroa
    • 3
  1. 1.Cancer Prevention Fellowship ProgramNational Cancer InstituteBethesdaUSA
  2. 2.Department of Pathology and Laboratory MedicineUniversity of CalgaryCalgaryCanada
  3. 3.Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and GeneticsNational Cancer InstituteBethesdaUSA
  4. 4.Genetic Epidemiology Branch, Division of Cancer Epidemiology and GeneticsNational Cancer InstituteBethesdaUSA
  5. 5.The Institute of Cancer ResearchLondonUK
  6. 6.Department of Cancer Epidemiology and PreventionCancer Center and M. Sklodowska-Curie Institute of OncologyWarsawPoland
  7. 7.Department of Environmental EpidemiologyNofer Institute of Occupational MedicineLodzPoland
  8. 8.Mammary Biology and Tumorigenesis Laboratory, Center for Cancer ResearchNational Cancer InstituteBethesdaUSA