Article

Hormones and Cancer

, Volume 1, Issue 5, pp 223-228

Androgen Action in Prostate Cancer

  • Sujit BasuAffiliated withDepartment of Pathology, Ohio State University
  • , Donald J. TindallAffiliated withDepartments of Urology and Biochemistry and Molecular Biology, Mayo Clinic College of Medicine Email author 

Abstract

Prostate cancer represents a major health problem in men worldwide. Androgens are required for the growth and maintenance of the prostate. Androgens act by binding to the androgen receptor (AR), a nuclear receptor transcription factor present in the prostate tissues. Most prostate tumors also retain their androgen dependence; therefore, androgen ablation is usually the preferred initial therapeutic approach for the treatment of advanced prostate cancer patients. This review summarizes the current information regarding the role of androgens in prostate cancer.

Keywords

Androgen Androgen ablation therapy Prostate