Indian Journal of Gastroenterology

, Volume 32, Issue 2, pp 103–107

Matrix metalloproteinase-9, transforming growth factor-β1, and tumor necrosis factor-α plasma levels in chronic pancreatitis

Authors

  • K. Sri Manjari
    • Institute of Genetics and Hospital for Genetic DiseasesOsmania University
  • A. Jyothy
    • Institute of Genetics and Hospital for Genetic DiseasesOsmania University
  • A. Vidyasagar
    • Department of GastroenterologyGandhi General Hospital
  • B. Prabhakar
    • Department of GastroenterologyOsmania General Hospital
  • Prathibha Nallari
    • Department of GeneticsOsmania University
    • Institute of Genetics and Hospital for Genetic DiseasesOsmania University
Original Article

DOI: 10.1007/s12664-012-0299-5

Cite this article as:
Manjari, K.S., Jyothy, A., Vidyasagar, A. et al. Indian J Gastroenterol (2013) 32: 103. doi:10.1007/s12664-012-0299-5

Abstract

Objective

The aim of the study was to investigate the plasma levels of matrix metalloproteinase-9 (MMP-9), transforming growth factor-β 1 (TGF-β1), and tumor necrosis factor-α (TNF-α) in chronic pancreatitis (CP).

Methods

Blood samples were obtained from 71 patients with CP and 100 control subjects, and plasma levels of MMP-9, TGF-β1, and TNF-α were determined by enzyme-linked immunosorbent assay.

Results

The plasma levels of MMP-9 (18.3 ± 3.0 ng/mL, p < 0.0001), TGF-β1 (215.4 ± 178.1 ng/mL, p = 0.0301), and TNF-α (111.2 ± 69.3 ng/mL, p < 0.001) were significantly elevated in CP compared to the control group.

Conclusion

The role of elevated plasma MMP-9, TGF-β1, and TNF-α in CP requires further evaluation.

Keywords

Extracellular matrixPancreatic fibrosisPancreatic stellate cells

Copyright information

© Indian Society of Gastroenterology 2013