, Volume 32, Issue 1, pp 64-65
Date: 15 Nov 2012

Rectal histoplasmosis in Job’s syndrome

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Sir:

Hyperimmunoglobulin E syndrome (Job’s syndrome, [JS]) described in 1966 [1], is a rare primary immunodeficiency disorder characterized by the triad of elevated serum IgE, recurrent cutaneous abscesses, and sino-pulmonary infections with >200 cases reported so far [2, 3]. Most cases are sporadic; however, autosomal dominant and recessive inheritance has been described. Neutrophil chemotaxis is abnormal due to decreased production of interferon gamma by T lymphocytes [4]. Presentation is usually early in life with recurrent staphylococcal and candidal infections, pneumonia, eczematoid skin, and facial, dental and skeletal abnormalities. The most common opportunistic infections include Pseudomonas, Aspergillus, Pneumocystis jiroveci, cryptococcosis, and histoplasmosis, with disseminated candidiasis and herpes simplex being less common [3]. Three reports of gastrointestinal (GI) (two ileocecal, one colonic) histoplasmosis in patients of JS have been reported till date [58]. We describ