Indian Journal of Gastroenterology

, Volume 32, Issue 4, pp 253–257

Survival comparison between surgical resection and percutaneous radiofrequency ablation for patients in Barcelona Clinic Liver Cancer early stage hepatocellular carcinoma

  • Kiong-Ming Wong
  • Ming-Lun Yeh
  • Shih-Chung Chuang
  • Liang-Yen Wang
  • Zu-Yau Lin
  • Shinn-Cherng Chen
  • Jung-Fa Tsai
  • Shen-Nien Wang
  • Kung-Kai Kuo
  • Chia-Yen Dai
  • Ming-Lung Yu
  • King-The Lee
  • Wan-Long Chuang
Original Article

DOI: 10.1007/s12664-012-0225-x

Cite this article as:
Wong, KM., Yeh, ML., Chuang, SC. et al. Indian J Gastroenterol (2013) 32: 253. doi:10.1007/s12664-012-0225-x

Abstract

Aim

To compare the survival outcome between surgical resection (SR) and radiofrequency ablation (RFA) for Barcelona Clinic Liver Cancer (BCLC) early stage hepatocellular carcinoma (HCC).

Methods

The retrospective study enrolled eighty-two patients with newly diagnosed BCLC early HCC (single nodule, size ≦3 cm, and Child-Pugh class A) treated either surgically (n = 46) or with RFA (n = 36) from year 2004 to 2009. The patients’ survival outcomes were compared.

Results

There were no significant differences in overall survival (OS) rates between SR and RFA (p = 0.204). The 3- and 5-year disease-free survival (DFS) rates were 65.8 % and 53.7 % respectively, in the SR group, which were significantly higher than those in the RFA group (34.8 % and 14.9 % respectively) (p = 0.009 and p = 0.001). In subgroup analysis, the DFS was similar between RFA and SR in patients with presentation of lower platelet count (≦100,000/mL) and smaller tumor size (tumor size ≦1 cm). Multivariate analysis showed SR as a procedure type was a significant predictive factor for DFS [HR = 2.26 (CI 1.462–5.227), p = 0.002].

Conclusion

SR yielded similar OS but better DFS when compared to RFA for patients with BCLC early HCC (single nodule, ≦3 cm and Child-Pugh class A). In subgroup patients with lower platelet count (≦100,000/mL) and smaller tumor size (tumor size ≦1 cm), DFS was similar between both treatments.

Keywords

Disease-free survival Hepatocellular carcinoma Overall survival Radiofrequency ablation Surgical resection 

Copyright information

© Indian Society of Gastroenterology 2012

Authors and Affiliations

  • Kiong-Ming Wong
    • 1
  • Ming-Lun Yeh
    • 1
  • Shih-Chung Chuang
    • 2
  • Liang-Yen Wang
    • 1
  • Zu-Yau Lin
    • 1
  • Shinn-Cherng Chen
    • 1
  • Jung-Fa Tsai
    • 1
  • Shen-Nien Wang
    • 2
  • Kung-Kai Kuo
    • 2
  • Chia-Yen Dai
    • 1
  • Ming-Lung Yu
    • 1
  • King-The Lee
    • 2
  • Wan-Long Chuang
    • 1
  1. 1.Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University HospitalKaohsiung Medical UniversityKaohsiungRepublic of China
  2. 2.Hepatobiliary Division, Department of Surgery, Kaohsiung Medical University HospitalKaohsiung Medical UniversityKaohsiungRepublic of China
  3. 3.Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Municipal Ta-Tung HospitalKaohsiung Medical UniversityKaohsiungRepublic of China

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