Indian Journal of Gastroenterology

, Volume 31, Issue 4, pp 165–170

Prevalence and predictors of abnormal bone mineral metabolism in recently diagnosed adult celiac patients

  • Sudheer D. Chakravarthi
  • Kapil Jain
  • Rakesh Kochhar
  • Sanjay K. Bhadada
  • Niranjan Khandelwal
  • Anil Bhansali
  • Usha Dutta
  • Chander K. Nain
  • Kartar Singh
Original Article

DOI: 10.1007/s12664-012-0216-y

Cite this article as:
Chakravarthi, S.D., Jain, K., Kochhar, R. et al. Indian J Gastroenterol (2012) 31: 165. doi:10.1007/s12664-012-0216-y

Abstract

Background and Aims

This study aimed to evaluate the prevalence of low bone mineral density (BMD) in recently diagnosed adult celiac patients and to identify the factors associated with this.

Methods

We investigated 54 newly diagnosed adult celiac patients between February 2008 and April 2009. BMD was measured in all patients and its correlation with clinical and biochemical parameters was analyzed.

Results

Fifty-four (24 male) newly diagnosed celiac patients with a mean±SD age of 30.6 ± 9.3 years (range 18–50) were included. Thirty-nine (72.2 %) presented with intestinal symptoms, and the rest with extraintestinal symptoms. Low vitamin D levels were seen in 11 (20.3 %) patients and elevated iPTH (secondary hyperparathyroidism) in 12 (22.2 %) patients. Twenty-one (39 %) patients had normal BMD, 23 (43 %) had osteopenia (T-score −1 to −2.5), and 10 (18 %) patients had osteoporosis (T-score <−2.5). A statistically significant association was seen between BMD and age of onset, duration of illness, serum tTGA levels, serum vitamin D levels, and histopathological changes.

Conclusions

Low BMD is common in newly diagnosed adult celiac patients with approximately one fifth of them having osteoporosis. BMD should be measured in all newly diagnosed celiac patients and calcium and vitamin D supplementation included in the treatment regimen.

Keywords

Adult celiac diseaseBone mineral densityCeliac disease

Supplementary material

12664_2012_216_MOESM1_ESM.doc (15 kb)
Supplementary Tables(DOC 15.0 kb)

Copyright information

© Indian Society of Gastroenterology 2012

Authors and Affiliations

  • Sudheer D. Chakravarthi
    • 1
  • Kapil Jain
    • 1
  • Rakesh Kochhar
    • 1
  • Sanjay K. Bhadada
    • 2
  • Niranjan Khandelwal
    • 3
  • Anil Bhansali
    • 2
  • Usha Dutta
    • 1
  • Chander K. Nain
    • 1
  • Kartar Singh
    • 1
  1. 1.Department of GastroenterologyPostgraduate Institute of Medical Education and ResearchChandigarhIndia
  2. 2.Department of EndocrinologyPostgraduate Institute of Medical Education and ResearchChandigarhIndia
  3. 3.Department of Radiodiagnosis and ImagingPostgraduate Institute of Medical Education and ResearchChandigarhIndia