Stress-induced cardiomyopathy following cephalosporin-induced anaphylactic shock during general anesthesia
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- Suk, E.H., Kim, D.H., Kweon, T.D. et al. Can J Anesth/J Can Anesth (2009) 56: 432. doi:10.1007/s12630-009-9083-0
Anaphylaxis may be caused by various agents during general anesthesia. Sympathetic discharge may occur during anaphylaxis, which can trigger transient cardiomyopathy. We describe a case of stress-induced cardiomyopathy that occurred in association with an anaphylactic reaction during general anesthesia.
A 32-year-old female undergoing laparoscopic enucleation of an ovarian cyst developed a severe anaphylactic reaction after cephalosporin infusion during general anesthesia. Her vital signs responded favourably to immediate resuscitative maneuvers, but cardiovascular collapse reappeared with transient ventricular tachycardia shortly after her transfer to the intensive care unit. ST-segment elevation appeared in electrocardiographic leads V2–V6 and echocardiography showed diffuse regional wall motion abnormalities in the midventricular level. Increased MB fractions of creatine kinase and troponin T levels indicated myocardial necrosis, but cardiac catheterization demonstrated normal coronary arteries. Management was supportive and she was discharged 2 days after the onset of anaphylactic symptoms, without sequelae. A diagnosis of stress-induced cardiomyopathy of a midventricular type following anaphylaxis was made on the basis of the clinical features and the findings of cardiac evaluations.
Transient, reversible left-ventricular dysfunction is a recently recognized phenomenon that may occur in the setting of anaphylactic reactions during the perioperative period.
Cardiomyopathie provoquée par le stress à la suite d’un choc anaphylactique causé par la céphalosporine durant une anesthésie générale
L’anaphylaxie peut être provoquée par différents agents pendant une anesthésie générale. Une décharge sympathique peut survenir pendant l’anaphylaxie, ce qui peut provoquer une cardiomyopathie transitoire. Nous décrivons un cas de cardiomyopathie provoquée par le stress survenue en association avec une réaction anaphylactique pendant l’anesthésie générale.
Une femme de 32 ans subissant une énucléation d’un kyste de l’ovaire par laparoscopie a manifesté une réaction anaphylactique grave après avoir reçu une perfusion de céphalosporine pendant l’anesthésie générale. Ses signes vitaux ont bien réagi aux manœuvres de réanimation immédiates, mais une défaillance cardiovasculaire est apparue, accompagnée d’une tachycardie ventriculaire transitoire, peu après son transfert à l’unité des soins intensifs. Un sus-décalage du segment ST a été observé dans les dérivations V2–V6 de l’électrocardiogramme, et l’échocardiographie a montré des anomalies régionales de contractilité de la paroi au niveau médio-ventriculaire. Des fractions MB plus élevées de créatine kinase et des niveaux de troponine T indiquaient une nécrose myocardique, mais une cathétérisation cardiaque a démontré des artères coronaires normales. Une prise en charge de soutien a été mise en place et la patiente a reçu son congé de l’hôpital sans séquelles deux jours après le début des symptômes d’anaphylaxie. Un diagnostic de cardiomyopathie de type médio-ventriculaire provoquée par le stress suite à une anaphylaxie a été posé sur la base des éléments cliniques et des résultats des évaluations cardiaques.
La dysfonction transitoire et réversible du ventricule gauche est un phénomène reconnu récemment qui peut survenir dans un contexte de réactions anaphylactiques pendant la période périopératoire.
Recent reports and review articles have described a transient left ventricular (LV) dysfunction that resembles acute myocardial infarction, but with normal coronary arteries.1–6 Various definitions have been proposed to describe this syndrome, such as stress-induced cardiomyopathy, Takotsubo cardiomyopathy, broken heart syndrome, apical ballooning syndrome, and transient LV dysfunction syndrome. This cardiomyopathy is usually triggered by stressful situations and can occur during the perioperative period when emotional and physical stress is common in patients undergoing operations. Several reports describe the onset of this unusual cardiomyopathy during induction of anesthesia and the intraoperative period.2,3 It can also occur immediately, hours, or days after surgery.4–6
Anaphylaxis occasionally develops during anesthesia, but it is unclear whether anaphylactic reactions are associated with stress-induced cardiomyopathy. To date, there has only been one published case of Takotsubo cardiomyopathy associated with anaphylaxis after food ingestion,7 and Han et al.8 described midventricular hypokinesis similar to this syndrome during contrast media-induced anaphylaxis. We report an unusual case of severe anaphylactic shock during general anesthesia followed by stress-induced cardiomyopathy. Consent for publication was obtained from the patient according to patient health information guidelines of the Yonsei University Health System.
A healthy 32-year-old woman weighing 47 kg presented for laparoscopic enucleation of an ovarian cyst. The patient had a history of allergic rhinitis and one episode of angioedema after ingesting shellfish. Her medical history was otherwise unremarkable. She was physically active and not taking any medications before surgery. There were no risk factors for coronary artery disease, and there was no family history of drug allergies.
Follow-up echocardiography the next day showed that the patient’s systolic function had improved and, compared with previous echocardiograms, regional wall motion abnormalities had resolved (EF = 66%), although mild hypokinesia of the LV posterolateral wall persisted (Fig. 2, Panels c, d). The ST segment elevations resolved on the patient’s ECG, and her coronary angiography revealed no evidence of obstructive coronary artery disease. She was discharged 2 days after the onset of anaphylaxis without sequelae and was able to return to normal activity, including exercise. An ECG performed before discharge showed normal sinus rhythm. On the basis of the clinical features and the echocardiographic findings, the patient was diagnosed with stress-induced cardiomyopathy of a midventricular type.
A skin prick test performed 6 weeks postoperatively was positive for cefotiam and negative for other drugs, including rocuronium, propofol, and midazolam.
As patients receive multiple medications, anaphylaxis after general anesthetic induction may be caused by various agents. In this case, the temporal relationship between drug administration and cardiovascular collapse and positive results in the skin prick test suggest that cefotiam, a second generation of cephalosporin, was the most likely cause of the reaction. The negative results of preoperative intradermal tests can be explained by the lower sensitivity of the tests. Cephalosporin anaphylaxis is rare, with a frequency of 0.0001–0.1% of the general population.
Stress-induced cardiomyopathy is characterized by acute onset of transient LV dysfunction in the absence of atherosclerotic coronary artery disease. Since the original description of this cardiomyopathy, several variants of this entity have been reported involving different segments of the LV wall. In the present case, there was preserved function of the apex of the LV with motion abnormalities in the midventricular segments. This type of cardiomyopathy was described as a variant observed in 40% of patients with this syndrome.9 In our patient, the constellation of findings of transient LV regional wall motion abnormality is consistent with stress-induced cardiomyopathy in that it extends beyond: (1) the vascular distribution of any single coronary artery in echocardiography;10 (2) the ECG changes mimicking myocardial infarction; (3) the moderate elevation of cardiac enzymes; and (4) the rapid resolution of LV dysfunction and normal coronary arteries. It predominantly affects elderly women, although, as in our case, younger patients are occasionally affected. There was no clinical evidence of concurrent conditions, such as pheochromocytoma and myocarditis, which must be ruled out in the differential diagnosis of this cardiomyopathy.1
The pathophysiological mechanism of stress-induced cardiomyopathy remains unclear, and it has not yet been determined whether anaphylaxis is associated with stress-induced cardiomyopathy. However, cardiovascular involvement is an important feature of anaphylaxis, and acute coronary syndromes have been sporadically reported during anaphylactic reactions in individuals with normal coronary arteries.11–13
Coronary arterial spasm was proposed as the main mechanism of anaphylaxis-induced coronary syndromes. It also was thought to be one of the triggering mechanisms of stress-induced cardiomyopathy. Kurisu et al.14 suggested that simultaneous multi-vessel coronary spasm at the epicardial artery or microvascular levels may contribute to onset of this type of cardiomyopathy. Therefore, coronary artery spasm by anaphylactic mediators may initiate stress-induced cardiomyopathy during anaphylactic reactions. Since the coronary angiography was not performed in our patient until the following day, we do not know whether coronary artery spasm existed in the acute state.
It has been suggested that the systemic catecholamine increase, with excessive activation of cardiac catecholamine receptors in the LV, plays a major role in the pathophysiology of stress-induced cardiomyopathy.15,16 In anaphylaxis, compensatory catecholamine is released by the renin-angiotensin-aldosterone system, and histamine stimulates the release of catecholamine by direct action on the adrenal medullary cells.17,18 In addition to this phenomenon, administration of catecholamines, such as epinephrine and norepinephrine, for hemodynamic support in anaphylactic shock would also increase the plasma catecholamine level. It is possible that the increased catecholamine levels during anaphylaxis may provoke stress-induced cardiomyopathy.
Accordingly, stress-induced cardiomyopathy may be precipitated by anaphylactic reactions through the two different mechanisms as described above. It is possible that some of the acute coronary symptoms, which have been reported during anaphylaxis in the presence of normal coronary arteries, might be related to this transient ventricular dysfunction.12,19,20
Stress-induced cardiomyopathy has only very recently become recognized as a cause of cardiac dysfunction during the perioperative period. The prevalence of stress-induced cardiomyopathy in the perioperative setting awaits large scale prospective cohort studies. A recent study of patients admitted to the medical ICU found that LV apical ballooning occurred in 28% of cases using echocardiography.21 Although it was not confirmed by coronary angiography, this report suggests that cardiomyopathy may develop in a number of patients. Considering that these perioperative events can induce severe physical and emotional stress and that the initial presentation of stress-induced cardiomyopathy is indistinguishable from acute myocardial ischemia, it is likely to be either unfamiliar or misinterpreted.
In this case, the patient recovered spontaneously with supportive therapy. Treatment of stress-induced cardiomyopathy relies on standard supportive measures. The prognosis is generally favourable, providing the patient survives the initial, severe state, since serious complications can occur during the initial phase of this cardiomyopathy. Cardiogenic shock, congestive heart failure, and death occur in 6.5%, 3.8%, and 3.2% of patients, respectively.22 Other rare complications have been reported, such as arrhythmia, pneumothorax, stroke, dynamic intraventricular obstruction, LV thrombosis, and free wall rupture.1 It is possible that cardiovascular collapse may become exacerbated if such complications develop during the acute anaphylactic state. Intraoperative transesophageal echocardiography during anesthesia may be very useful in the detection and management of this unusual form of LV dysfunction and its complications.
In summary, we describe a case of atypical stress-induced cardiomyopathy associated with cephalosporin-induced anaphylaxis during anesthesia. Possible mechanisms are discussed. There is a potential for occurrence of this cardiomyopathy during the course of an anaphylactic reaction, particularly in the perioperative period. Anaphylaxis and stress-induced cardiomyopathy are both life-threatening events in the acute phase; therefore, anesthesiologists should be aware of this recently recognized form of transient LV dysfunction and its serious complications. We suggest that echocardiography is an effective tool for both early diagnosis of cardiomyopathy in patients with anaphylaxis, and for therapy guidance during the perioperative period.
Conflicts of interest
The authors declare no competing financial interests.