The journal of nutrition, health & aging

, Volume 18, Issue 1, pp 15–21

A path model of sarcopenia on bone mass loss in elderly subjects

  • Mariangela Rondanelli
  • D. Guido
  • A. Opizzi
  • M. A. Faliva
  • S. Perna
  • M. Grassi
Article

DOI: 10.1007/s12603-013-0357-4

Cite this article as:
Rondanelli, M., Guido, D., Opizzi, A. et al. J Nutr Health Aging (2014) 18: 15. doi:10.1007/s12603-013-0357-4

Abstract

Objective

Aging is associated with decreases in muscle mass, strength, power (sarcopenia) and bone mineral density (BMD). The aims of this study were to investigate in elderly the role of sarcopenia on BMD loss by a path model, including adiposity, inflammation, and malnutrition associations.

Methods

Body composition and BMD were measured by dual X-ray absorptiometry in 159 elderly subjects (52 male/107 female; mean age 80.3 yrs). Muscle strength was determined with dynamometer. Serum albumin and PCR were also assessed. Structural equations examined the effect of sarcopenia (measured by Relative Skeletal Muscle Mass, Total Muscle Mass, Handgrip, Muscle Quality Score) on osteoporosis (measured by Vertebral and Femoral T-scores) in a latent variable model including adiposity (measured by Total Fat Mass, BMI, Ginoid/Android Fat), inflammation (PCR), and malnutrition (serum albumin).

Results

The sarcopenia assumed a role of moderator in the adiposity-osteoporosis relationship. Specifically, increasing the sarcopenia, the relationship adiposity-osteoporosis (β: −0.58) decrease in intensity. Adiposity also influences sarcopenia (β: −0.18). Malnutrition affects the inflammatory and the adiposity states (β: +0.61, and β: −0.30, respectively), while not influencing the sarcopenia. Thus, adiposity has a role as a mediator of the effect of malnutrition on both sarcopenia and osteoporosis. Malnutrition decreases adiposity; decreasing adiposity, in turn, increase the sarcopenia and osteoporosis.

Conclusions

This study suggests such as in a group of elderly sarcopenia affects the link between adiposity and BMD, but not have a pure independent effect on osteoporosis.

Key words

Bone mineral densityelderlyrelative skeletal muscle masssarcopenialatent variables

Copyright information

© Serdi and Springer-Verlag France 2014

Authors and Affiliations

  • Mariangela Rondanelli
    • 1
    • 3
  • D. Guido
    • 2
  • A. Opizzi
    • 1
  • M. A. Faliva
    • 1
  • S. Perna
    • 1
  • M. Grassi
    • 2
  1. 1.Department of Public Health, Experimental and Forensic Medicine, Section of Human Nutrition and Dietetics, Azienda di Servizi alla Persona di PaviaUniversity of PaviaPaviaItaly
  2. 2.Department of Brain and Behavioural Sciences, Medical Statistics and Genomics UnitUniversity of PaviaPaviaItaly
  3. 3.Department of Public Health, Section of Human Nutrition and Dietetics, Faculty of MedicineUniversity of Pavia, Endocrinology and Nutrition Unit, ASPPaviaItaly