Article

The journal of nutrition, health & aging

, Volume 17, Issue 7, pp 619-623

How to design nutritional intervention trials to slow cognitive decline in apparently healthy populations and apply for efficacy claims: A statement from the international academy on nutrition and aging task force

  • M. FerryAffiliated withNutritional Epidemiology Unit, U557 INSERM/U1125 Inra/Cnam/University Paris 13Nutritional Epidemiology Unit, Human Nutrition Research Center of Ile de France, UFR SMBH Paris 13 Email author 
  • , N. ColeyAffiliated withINSERM U1027University of Toulouse III
  • , S. AndrieuAffiliated withINSERM U1027University of Toulouse IIIGérontopôle, Toulouse University HospitalDepartment of Epidemiology and Public Health
  • , C. BonhommeAffiliated withLactalis Nutrition Santé
  • , J. P. CaubereAffiliated withPierre Fabre
  • , M. CesariAffiliated withINSERM U1027University of Toulouse IIIGérontopôle, Toulouse University Hospital
  • , J. GautryAffiliated withNestlé Clinical Nutrition
  • , I. Garcia SanchezAffiliated withDG Sanco
  • , L. HugonotAffiliated withNutritional Epidemiology Unit, U557 INSERM/U1125 Inra/Cnam/University Paris 13MedForma
    • , L. MansuyAffiliated withPierre Fabre
    • , M. PahorAffiliated withNutritional Epidemiology Unit, U557 INSERM/U1125 Inra/Cnam/University Paris 13University of Floride
    • , J. ParienteAffiliated withNutritional Epidemiology Unit, U557 INSERM/U1125 Inra/Cnam/University Paris 13Department of Neurology, Purpan Hospital
    • , P. RitzAffiliated withNutritional Epidemiology Unit, U557 INSERM/U1125 Inra/Cnam/University Paris 13Nutrition Unit, Toulouse University Hospital
    • , A. SalvaAffiliated withNutritional Epidemiology Unit, U557 INSERM/U1125 Inra/Cnam/University Paris 13Institut Català de l’Envelliment, Universita Autonoma de Barcelona
    • , J. SijbenAffiliated withNutritional Epidemiology Unit, U557 INSERM/U1125 Inra/Cnam/University Paris 13Nutricia Advanced Medical Nutrition, Danone Research, Centre for Specialized Nutrition
    • , R. WieggersAffiliated withNutritional Epidemiology Unit, U557 INSERM/U1125 Inra/Cnam/University Paris 13Nutricia Advanced Medical Nutrition, Danone Research, Centre for Specialized Nutrition
    • , P. Ythier-MouryAffiliated withNutritional Epidemiology Unit, U557 INSERM/U1125 Inra/Cnam/University Paris 13Sanofi R&D — TSU Aging
    • , M. ZaimAffiliated withNutritional Epidemiology Unit, U557 INSERM/U1125 Inra/Cnam/University Paris 13Institut de Recherche Pierre Fabre
    • , J. ZetlaouiAffiliated withNutritional Epidemiology Unit, U557 INSERM/U1125 Inra/Cnam/University Paris 13Nestlé Health Science SA
    • , B. VellasAffiliated withINSERM U1027University of Toulouse IIIGérontopôle, Toulouse University Hospital

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Abstract

interventions are crucial as they offer simple and inexpensive public health solutions that will be useful over the long term use. A Task Force on designing trials of nutritional interventions to slow cognitive decline in older adults was held in Toulouse in September 2012. The aim of the Task Force was to bring together leading experts from academia, the food industry and regulatory agencies to determine the best trial designs that would enable us to reach our goal of maintaining or improving cognitive function in apparently healthy aging people. An associated challenge for this Task Force was to determine the type of trials required by the Public Food Agencies for assessing the impact of nutritional compounds in comparison to well established requirements for drug trials. Although the required quality of the study design, rationale and statistical analysis remains the same, the studies designed to show reduction of cognitive decline require a long duration and the objectives of this task force was to determine best design for these trials. Two specific needs were identified to support trials of nutritional interventions: 1- Risk-reduction strategies are needed to tackle the growing burden of cognitive decline that may lead to dementia, 2- Innovative study designs are needed to improve the quality of these studies.

Key words

Cognitive decline aging design nutritional intervention trials efficacy claims