Elevated homocysteine levels are associated with low muscle strength and functional limitations in older persons
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The current study aimed to examine homocysteine in relation to different aspects of physical functioning.
Design, setting and participants
Cross-sectional and longitudinal data (3-years follow-up) from the Longitudinal Aging Study Amsterdam (LASA) were used. The study was performed in persons aged ≥ 65 years (N= 1301 after imputation).
Different measures of physical functioning, including muscle mass, grip strength, functional limitations, and falling were regarded as outcomes. Gender and serum creatinine level were investigated as effect modifiers.
Results were stratified by gender. In men, higher homocysteine levels were associated with lower grip strength (Quartile 4: regression coefficient (B)= −3.07 (−4.91; −1.22)), and more functional limitations at baseline (Quartile 4: B= 1.15 (0.16–2.14)). In women, higher homocysteine levels were associated with more functional limitations after 3 years (Quartile 4: B= 1.19 (0.25; 2.13)). Higher homocysteine levels were not associated with low muscle mass or falling.
These data suggest an inverse association of homocysteine levels with functional limitations in older men and women, and with muscle strength in older men.
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- Elevated homocysteine levels are associated with low muscle strength and functional limitations in older persons
The journal of nutrition, health & aging
Volume 17, Issue 6 , pp 578-584
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- physical functioning
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- 147. Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, the Netherlands
- 447. Department of Epidemiology and Biostatistics, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, the Netherlands
- 247. Institute of Health Sciences, Faculty of Earth and Life Sciences, EMGO Institute for Health and Care Research, VU University, P.O. Box 7057, 1007 MB, Amsterdam, the Netherlands
- 347. Department of Internal Medicine, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, the Netherlands