The journal of nutrition, health & aging

, Volume 17, Issue 5, pp 426–433

Micronutrients-incorporated calcium phosphate particles with protective effect on osteoporotic bone tissue

  • X. Chen
  • L. Zhang
  • X. Yang
  • Z. Li
  • X. Sun
  • M. Lin
  • G. Yang
  • Zongru Gou
Article

DOI: 10.1007/s12603-013-0006-y

Cite this article as:
Chen, X., Zhang, L., Yang, X. et al. J Nutr Health Aging (2013) 17: 426. doi:10.1007/s12603-013-0006-y

Abstract

Background

Supplementation of individual micronutrient is inadequate for maintaining bone function because single micronutrient can not contribute significantly a positive remodeling balance.

Objective

We developed the highly integrated, stably dietary multi-micronutrients with good bioavailability and low adverse effect on the improvement of bone consolidation in osteoporosis.

Methods

The trace element-codoped calcium phosphate (teCaP) particles were prepared in the modified body fluid and carefully evaluated. Rats, aged 3 months, were ovariectomized and when 6 month intervened with the conditioned, low, moderate, and high teCaP diets.

Results

The teCaP particles showed highly dissolvable in stomach juice-mimicing acidic solutions. Three months after intervention, the body weight increase showed remarkable differences among the low teCaP diet (∼52 g), moderate teCaP diet (∼34 g) and high teCaP diet (∼23 g) group. In particular, the intake of moderate teCaP greatly improved the retention of trace elements in femural bone for better protection against the skeletal weakening, and resulted in a significant increase of bone mineral density (104.06%) in comparison with the conventional high calcium plus vitamin D3 diet (Control group).

Conclusions

These investigations improve our understanding of micronutrient retention on bone consolidation in osteoporotic bone tissue, and also provide new mild wet-chemical approach to prepare potent nutritionally effective edible complements to synergistically relieve bone degeneration and prevent osteoporosis.

Key words

Micronutrient trace element calcium phosphate dietary supplement antiosteoporosis 

Copyright information

© Serdi and Springer-Verlag France 2013

Authors and Affiliations

  • X. Chen
    • 1
  • L. Zhang
    • 2
  • X. Yang
    • 1
  • Z. Li
    • 1
  • X. Sun
    • 2
  • M. Lin
    • 2
  • G. Yang
    • 2
  • Zongru Gou
    • 1
    • 3
  1. 1.Zhejiang-California International Nanosystems InstituteZhejiang UniversityHangzhouChina
  2. 2.Rui’an People’s Hospital & the 3rd Hospital Affiliated to Wenzhou Medical CollegeRuianChina
  3. 3.Dr. Bio-nanomaterials and Regenerative Medicine Research Division, Zhejiang-California International Nanosystems InstituteZhejiang UniversityHangzhouChina