Mortality as an adverse outcome of sarcopenia
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Sarcopenia has an important impact in elderly. Recently the European Working Group on Sarcopenia in Older People (EWGSOP) defined sarcopenia as the loss of muscle mass plus low muscle strength or low physical performance. Lack of clinical sounding outcomes (ie external validity), is one of the flaws of this algorithm. The aim of our study was to determine the association of sarcopenia and mortality in a group of Mexican elderly. A total of 345 elderly were recruited in Mexico City, and followed up for three years. The EWGSOP algorithm was integrated by: gait speed, grip strength and calf circumference. Other covariates were assessed in order to test the independent association of sarcopenia with mortality. Of the 345 subjects, 53.3% were women; with a mean age of 78.5 (SD 7) years. During the three year follow-up a total of 43 (12.4%) subjects died. Age, cognition, ADL, IADL, health self-perception, ischemic heart disease and sarcopenia were associated in the bivariate analysis with survival. Negative predictive value for sarcopenia regarding mortality was of 90%. Kaplan-Meier curves along with their respective log-rank test were significant for sarcopenia. The components of the final Cox-regression multivariate model were age, ischemic heart disease, ADL and sarcopenia. Adjusted HR for age was 3.24 (CI 95% 1.55–6.78 p 0.002), IHD 5.07 (CI 95% 1.89–13.59 p 0.001), health self-perception 5.07 (CI 95% 1.9–13.6 p 0.001), ADL 0.75 (CI 95% 0.56–0.99 p 0.048) and sarcopenia 2.39 (CI 95% 1.05–5.43 p 0.037).
- Baumgartner RN, Koehler KM, Gallagher D, Romero L, Heymsfield SB, et al (1998) Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol, 1998. 147: 755–763. CrossRef
- Thompson DD (2007) Aging and sarcopenia. J Musculoskelet Neuronal Interact. 7: 344–345.
- Roubenoff R (2001) Origins and clinical relevance of sarcopenia. Can J Appl Physiol 26: 78–89. CrossRef
- Lauretani F, Russo CR, Bandinelli S, Bartali B, Cavazzini C, et al (2003) Ageassociated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia. J Appl Physiol 95: 1851–1860.
- Janssen I (2010) Evolution of sarcopenia research. Appl Physiol Nutr Metab 35: 707–712. doi: 10.1139/H10-067 CrossRef
- Abellan van Kan G (2009) Epidemiology and consequences of sarcopenia. J Nutr Health Aging 13: 708–712. CrossRef
- Arango-Lopera VE, Arroyo, P, Gutiérrez-Robledo LM, Pérez-Zepeda MU (2012) Prevalence of sarcopenia in Mexico City. Eur Geriatr Med. doi:10.1016/j.eurger.2011.12.001.
- Fielding RA, Vellas B, Evans WJ, Bhasin S, et al (2011) Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia. J Am Med Dir Assoc 12: 249–256. doi: 10.1016/j.jamda.2011.01.003 CrossRef
- Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, et al (2010) Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing 39(4): p. 412–423. doi: 10.1093/ageing/afq034 CrossRef
- Patel HP, Syddall HE, Martin HJ, Stewart CE, Cooper C, Sayer AA, et al (2010) Hertfordshire sarcopenia study: design and methods. BMC Geriatr 10: 43. doi: 10.1186/1471-2318-10-43 CrossRef
- Villareal DT, Banks M, Siener C, Sinacore DR, Klein S (2004) Physical frailty and body composition in obese elderly men and women. Obes Res 12: 913–920. doi: 10.1038/oby.2004.111 CrossRef
- Inouye SK, Studenski S, Tinetti ME, Kuchel GA (2007) Geriatric syndromes: clinical, research, and policy implications of a core geriatric concept. J Am Geriatr Soc 55: 780–791. doi: 10.1111/j.1532-5415.2007.01156.x CrossRef
- Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, et al (2001) Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56: p. M146–156. CrossRef
- Bauer JM, Sieber CC (2008) Sarcopenia and frailty: a clinician’s controversial point of view. Exp Gerontol 43: 674–678. doi: 10.1016/j.exger.2008.03.007 CrossRef
- Mexico City Government, Padrón de Beneficiarios del Programa de Pensión Alimentaria del Distrito Federal, 2011, Gobierno del Distrito Federal: http://www.sideso.df.gob.mx/index.php?id=399. Accessed 20 July 2011.
- Rolland Y, Lauwers-Cances V, Cournot M, Nourhashémi F, Reynish W, et al (2003) Sarcopenia, calf circumference, and physical function of elderly women: a crosssectional study. J Am Geriatr Soc 51: 1120–1124. CrossRef
- Franco-Marina F, García-González JJ, Wagner-Echeagaray F, Gallo J, García-Peña C, et al (2010) The Mini-mental State Examination revisited: ceiling and floor effects after score adjustment for educational level in an aging Mexican population. Int Psychogeriatr 22: 72–81. doi: 10.1017/S1041610209990822 CrossRef
- Rueda-Jaimes GE, Lopez-Camargo MT, Campo-Arias A (2009) [Validacion de una version abreviada de la Escala para Depresion del Centro de Estudios Epidemiologicos (CES-D) en adultos colombianos] Rev Colomb Psiquiatr 38: 734–745.
- Katz S (1983) Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. J Am Geriatr Soc 3: 721–727.
- Lawton MP, Brody EM (1969) Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 9: 179–186. CrossRef
- Podsiadlo D, Richardson S (1991) The timed “Up & Go”: a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc 39: 142–148.
- Guigoz Y, Vellas B, Garry PJ (1996) Assessing the nutritional status of the elderly: The Mini Nutritional Assessment as part of the geriatric evaluation. Nutr Rev 54: S59–65. CrossRef
- Ensrud KE, Ewing SK, Taylor BC, Fink HA, Cawthon PM (2008) Comparison of 2 frailty indexes for prediction of falls, disability, fractures, and death in older women. Arch Intern Med 168: 382–389. CrossRef
- Bunout D, de la Maza MP, Barrera B, Leiva L, Hirsch S (2011) Association between sarcopenia and mortality in healthy older people. Australas J Ageing 30: 89–92. doi: 10.1111/j.1741-6612.2010.00448.x CrossRef
- Landi F, Liperoti R, Fusco D, Mastropaolo S, Quattrociocchi D, et al (2011) Sarcopenia and Mortality among Older Nursing Home Residents. J Am Med Dir Assoc. doi: 10.1016/j.jamda.2011.07.004
- Mortality as an adverse outcome of sarcopenia
The journal of nutrition, health & aging
Volume 17, Issue 3 , pp 259-262
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- nutrition in elderly
- Industry Sectors
- Author Affiliations
- 1434. Education Department at Instituto de Geriatría, México D.F, México
- 2434. Research Department at Instituto de Geriatría, México D.F, México
- 3434. Instituto de Geriatría, México D.F, México
- 5434. Instituto de Geriatría, Periférico Sur 2767, san Jerónimo Lídice, Magdalena Contreras, México D.F., 10200, México
- 4434. Gerontopole; Toulouse, France